Molecular Characterization and Potential Inhibitors Prediction of Protein Arginine Methyltransferase-2 in Carcinoma: An Insight from Molecular Docking, ADMET Profiling and Molecular Dynamics Simulation Studies.

Objectives: To predict and characterize the three-dimensional (3D) structure of protein arginine methyltransferase 2 (PRMT2) using homology modeling, besides, the identification of potent inhibitors for enhanced comprehension of the biological function of this protein arginine methyltransferase (PRMT) family protein in carcinogenesis.

Materials And Methods: An method was employed to predict and characterize the three-dimensional structure. The bulk of PRMTs in the PDB shares just a structurally conserved catalytic core domain.

Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation Exposure.

This study investigated the lifetime attributable risk (LAR) of radiation-induced breast cancer from mammography screening in Dubai. It aimed to explore the relationship between breast thickness, patient age, and the associated radiation dose during mammographic examinations. A retrospective analysis was conducted on 2601 patients aged 40 to 69 across five screening facilities in Dubai's healthcare system.

A Critical Appraisal of System-Reported Organ Dose (OD) Versus Manually Calculated Mean Glandular Dose (MGD) in Dubai's Mammography Services.

: This study compares system-reported organ doses (ODs) to manually calculated mean glandular doses (MGDs) in mammography across multiple centers and manufacturers in Dubai. : A retrospective study of 2754 anonymized mammograms from six clinics in Dubai were randomly retrieved from a central dose survey database. Organ doses were documented along with other dosimetry information like kVp, mAs, filter, target, compression force, and breast thickness.

Single Precursor-Derived Sub-1 nm MoCo Bimetallic Particles Decorated on Phosphide-Carbon Nitride Framework for Sustainable Hydrogen Generation.

The strategic design and fabrication of efficient electrocatalysts are pivotal for advancing the field of electrochemical water splitting (EWS). To enhance EWS performance, integrating non-noble transition metal catalysts through a cooperative double metal incorporation strategy is important and offers a compelling alternative to conventional precious metal-based materials. This study introduces a novel, straightforward, single-step process for fabricating a bimetallic MoCo catalyst integrated within a three-dimensional (3D) nanoporous network of N, P-doped carbon nitride derived from a self-contained precursor.

The Integration of Microwave-Synthesized Silver Colloidal Nanoparticles into Poly (Lactic Acid)-Based Textiles as Antimicrobial Agents via Pre- and Post-Electrospinning Processes.

This study introduces a novel method to enhance the antibacterial functionality of electrospun nanofibrous textiles by integrating silver nanoparticles (AgNPs) into poly (lactic acid) (PLA) fabrics through pre- and post-electrospinning techniques. AgNPs were incorporated into hydrophobic and modified hydrophilic PLA textiles via pre-solution blending and post-solution casting. A PEG-PPG-PEG tri-block copolymer was utilized to enhance hydrophilicity and water stability, while AgNPs served as antibacterial agents.