Publications by authors named "M Yanagimachi"
Objective: Chimerism analysis is an important post-transplant assessment for allogeneic hematopoietic stem cell transplant (HCT) recipients. Although various chimerism analysis techniques are already established, they are limited in terms of sensitivity, versatility, and turnaround time. Our objective was to develop a digital droplet polymerase chain reaction (ddPCR) assay for chimerism analysis using ABO gene polymorphisms as markers.
View Article and Find Full Text PDFPurpose: The JCCG ALL-B12 clinical trial aimed to evaluate the effectiveness of unvalidated treatment phases for pediatric ALL and develop a safety-focused treatment framework.
Patients And Methods: Patients age 1-19 years with newly diagnosed B-ALL were enrolled in this study. These patients were stratified into standard-risk (SR), intermediate-risk (IR), and high-risk (HR) groups.
Article Synopsis
- * A novel FBXW7 variant was found in a patient with intellectual disability who also developed Wilms tumor, indicating a potential genetic link.
- * The study suggests that the tumor's development may follow a two-hit model, highlighting the need for further research to improve management and monitoring strategies.
A Retrospective Study of Pediatric Patients With Low- or Intermediate-Risk Acute Myeloid Leukemia Who Underwent Allogeneic Hematopoietic Cell Transplantation for the AML-05 Study Conducted by the Japanese Pediatric Leukemia/Lymphoma Study Group.
Transplant Cell Ther
November 2024
Article Synopsis
- - The AML-05 study focused on evaluating a risk-based treatment approach for children with acute myeloid leukemia (AML), determining that allogeneic hematopoietic cell transplantation (allo-HCT) wasn’t necessary for low- or intermediate-risk patients in their first complete remission.
- - A retrospective analysis identified key prognostic factors for survival in 79 pediatric patients who underwent allo-HCT, highlighting umbilical cord blood (UCB) as a particularly favorable donor source for low-risk patients, along with late relapse being advantageous for intermediate-risk patients.
- - The study found significant differences in three-year outcomes like overall survival (OS) and event-free survival (EFS) between low- and intermediate-risk groups, suggesting
We herein report a patient with herpes zoster (HZ), severe hyponatremia, and hypokalemia. Syndrome of inappropriate antidiuresis (SIAD) leads to euvolemic hyponatremia and hypoosmotic plasma due to inadequate diuresis. Hyponatremia in the current patient was caused by SIAD and associated with HZ of the trigeminal facial nerve (V1).
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