Function of orexin-1 receptor signaling in the olfactory tubercle in odor-guided attraction and aversion.

While olfactory behaviors are influenced by neuromodulatory signals, the underlying mechanism remains unknown. The olfactory tubercle (OT), a component of the olfactory cortex and ventral striatum, consists of anteromedial (am) and lateral (l) domains regulating odor-guided attractive and aversive behaviors, respectively, in which the amOT highly expresses various receptors for feeding-regulated neuromodulators. Here we show functions of appetite-stimulating orexin-1 receptor (OxR1) signaling in the amOT.

Image quantification analysis of cytoplasmic mucin and interpretation of mucin color in lobular endocervical glandular hyperplasia.

Introduction: Although the widespread use of screening tests and HPV vaccines for squamous cell carcinoma has led to early detection and treatment, effectiveness is limited for cervical adenocarcinoma. Lobular endocervical glandular hyperplasia (LEGH) corresponds to gastric metaplasia, but is regarded as a pathological condition with subtle morphological abnormalities. LEGH is a benign lesion and a precursor to gastric-type adenocarcinoma.

Successful transcatheter edge-to-edge repair for tricuspid regurgitation in a patient with a double-inlet left ventricle and discordant connections of the great arteries: a case report.

Background: In patients with adult congenital heart disease (ACHD), significant atrioventricular valve regurgitation is an important risk factor for poor outcomes, such as heart failure. However, in many cases, transcatheter intervention may reduce the risk profile to avoid a high surgical risk.

Case Summary: A 44-year-old man with complex ACHD in the form of a double-inlet left ventricle, congenitally corrected transposition of the great arteries, pulmonary atresia, atrial septal defect, and patent ductus arteriosus was referred for the treatment of severe tricuspid regurgitation.

Efficacy of Laser Activated versus Sonic Activated Irrigation for Debris Removal in Conservatively Instrumented Root Canals.

Introduction: To compare the efficacy of laser activated and sonic activated irrigation on the removal of debris in mesial root canal systems of mandibular molars using micro-computed tomographic analysis.

Methods: Forty-eight mesial roots of extracted mandibular molars with isthmus were selected and randomly allocated into 2 groups: Sonic Group and Laser Group. The root canals were minimally instrumented to a maximum apical file size of 20/06v (DCTaper, SSWhite, NJ).

[Application of High-performance Liquid Chromatography to Caprolactam Migration Testing of Food Utensils, Containers, and Packaging].

We assessed the applicability of high-performance liquid chromatography (HPLC) to the official testing method for the migration of caprolactam (CPL) from food utensils, containers, and packaging made from polyamide (PA). Hydrophilic interaction chromatography (HILIC) columns coated with unmodified silica, carbamoyl, and aminopropyl were used. Water and acetonitrile (ACN) were used as the mobile phase, and the analytical conditions were optimized.