Publications by authors named "M Y Yip"
Article Synopsis
- Herpes zoster is a common infection that poses significant risks to immunocompromised individuals, leading to a recommendation for the recombinant zoster vaccine (RZV).
- A systematic review of studies found that RZV is highly effective, reducing herpes zoster incidence by 81% in immunocompromised adults while boosting immunity one month after vaccination.
- Although RZV was associated with increased local and systemic side effects, there were no notable differences in serious adverse events or death rates compared to placebo, indicating it is generally safe for use in this population.
Significant technical challenges exist when measuring synaptic connections between neurons in living brain tissue. The patch clamping technique, when used to probe for synaptic connections, is manually laborious and time-consuming. To improve its efficiency, we pursued another approach: instead of retracting all patch clamping electrodes after each recording attempt, we cleaned just one of them and reused it to obtain another recording while maintaining the others.
View Article and Find Full Text PDFThe diagnosis of retinopathy of prematurity (ROP) is primarily image-based and suitable for implementation of artificial intelligence (AI) systems. Increasing incidence of ROP, especially in low and middle-income countries, has also put tremendous stress on health care systems. Barriers to the implementation of AI include infrastructure, regulatory, legal, cost, sustainability, and scalability.
View Article and Find Full Text PDFInnate immunity senses microbial ligands known as pathogen-associated molecular patterns (PAMPs). Except for nucleic acids, PAMPs are exceedingly taxa-specific, thus enabling pattern recognition receptors to detect cognate pathogens while ignoring others. How the E3 ubiquitin ligase RNF213 can respond to phylogenetically distant pathogens, including Gram-negative Salmonella, Gram-positive Listeria, and eukaryotic Toxoplasma, remains unknown.
View Article and Find Full Text PDFSignificant technical challenges exist when measuring synaptic connections between neurons in living brain tissue. The patch clamping technique, when used to probe for synaptic connections, is manually laborious and time-consuming. To improve its efficiency, we pursued another approach: instead of retracting all patch clamping electrodes after each recording attempt, we cleaned just one of them and reused it to obtain another recording while maintaining the others.
View Article and Find Full Text PDF