Biodegradable pH-sensitive prospidine-loaded dextran phosphate based hydrogels for local tumor therapy.

The paper focuses on the development of drug delivery systems based on hydrogels of dextran phosphate (DP) for local cancer therapy. The hydrogels were characterized by physicochemical properties including functional group content, morphology, gel fraction, pH-responsive swelling. The desirable pH-sensitive drug release behavior of these hydrogels was demonstrated by a drug release test with Prospidine-loaded hydrogels (DP-Pr hydrogels) at different pH values.

[Possibilities of intraoperative thermal chemotherapy in radical surgery for advanced gastric cancer pt4a-4bn0-3M0].

The paper evaluates results of randomized study of treatment of 135 patients for II-IIIB stage resectable gastric cancer (Borrmann type III and IV); of them 70 underwent intraoperative hyperthermic chemotherapy based on a technique adopted in the clinic. It has been noted the improvement of long-term results in particular the increase of dissemination-free survival (plog-rank=0,004) especially in patients with absence of metastases in regional lymph nodes (pN0) - (plog-rank=0,03). Application of an integrated technique appears to improve remote results thereby necessitating the need for further studies.

[Antineoplastic effect of hydrogel prospidin on Seidel ascites hepatoma used as a model].

Antineoplastic effect of hydrogel dextran phosphate, hydrogel prospidin, and prospidin in an injectable preparation has been assessed using Seidel ascites hepatoma as a model. Injectable and hydrogel prospidin in doses from 250, 500 to 1000 mg/kg and hydrogel phosphate dextran in doses of 500 and 1000 mg/kg were administered to rats intraperitoneally in a single dose in a volume of 1 or 2 ml per each 100 g of animal body weight. The study has shown that irrespective of rats with Seidel ascites hepatoma and significantly increase in the dosage of prospidin preparations and hydrogel dextran phosphate results in a longer average life expectancy of rats Compared with its injectable variant, hydrogel prospidin appears to produce more than twice as high antineoplastic effect, and is found to provide prolonged therapeutic effects, as well as cure of animals in more than 60 % of cases.