Publications by authors named "M Y Mooty"
Article Synopsis
- The study investigates the effectiveness of two antibiotics, ceftazidime-avibactam (CZA) and ceftolozane-tazobactam (C/T), in treating multidrug-resistant Pseudomonas aeruginosa infections in patients on renal replacement therapy.
- A total of 45 patients were analyzed, with similar clinical cure rates for both CZA (48%) and C/T (60%), and no significant differences in outcomes such as microbiologic cure, recurrence, or 30-day mortality.
- The results suggest that both antibiotics are equally effective for clinical cure in the studied population, but further research with larger sample sizes is necessary to validate these findings.
Purpose: The clinical efficacy and safety of ertapenem use in patients undergoing renal replacement therapies (RRT) are not well-documented. Therefore, we aimed to investigate the safety and efficacy of ertapenem in patients with sepsis secondary to Enterobacterales who are undergoing RRT.
Methods: A retrospective cohort study was conducted on patients who met the inclusion criteria at our hospital between May 2015 and December 2021.
Article Synopsis
- This study investigated the effectiveness of Trimethoprim-sulfamethoxazole (TMP/SMZ) in critically ill patients with infections undergoing renal replacement therapies (RRT), focusing on clinical outcomes such as cure rates and mortality.
- Out of 45 patients analyzed, only 40% achieved clinical success while 60% failed treatment, with a significantly higher mortality rate (44.4%) in the clinical failure group.
- The research found that higher daily doses of TMP/SMZ at therapy initiation were linked to better clinical outcomes, highlighting the importance of dosage in treatment effectiveness for these patients.
Introduction: The suggested dose of ceftazidime-avibactam (CEF/AVI) in patient with multidrug resistant organisms and utilizing renal replacement therapies (RRTs) is not validated in clinical studies. The objective of this study was to evaluate the microbiologic cure of bacteremia and pneumonia using the recommended CEF/AVI dosing in patients utilizing RRT.
Methods: A retrospective observational study conducted at our institution between September 15, 2018 and March 15, 2022.
Background: Major infectious diseases societies recommend the use of antimicrobials that achieve high-urinary concentrations to treat urinary tract infection (UTI), which is a concept of little relevance to the oliguric and anuric hemodialysis (HD) dependent population. Outcome studies in this population are more relevant, but unfortunately scarce. We sought to investigate the impact of different antimicrobials on clinical and microbiologic outcomes in HD dependent population.
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