Publications by authors named "M Y Hussaini"
The shift toward a histo-molecular approach in World Health Organization classification of central nervous system tumors (WHO CNS5) emphasizes the critical role of molecular testing, such as next-generation sequencing (NGS) and DNA methylation profiling, for accurate diagnosis. However, implementing these advanced techniques is particularly challenging in resource-constrained countries. To address this, the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions (AOSNP-ADAPTR) was initiated to help pathologists in resource-limited regions to implement WHO CNS5 diagnoses using simpler diagnostic tools, mainly immunohistochemistry.
View Article and Find Full Text PDFThe mutations in and genes are frequently present in various myeloid neoplasms. The potential impact of / co-mutations on patient survival is incompletely understood. We identified 412 patients with / co-mutations from our NextGen sequencing database of around 8000 patients and reported likely the largest cohort study.
View Article and Find Full Text PDFArticle Synopsis
- Adult medulloblastoma is uncommon, and treatment insights are mostly drawn from studies of pediatric cases; this study analyzed adult cases treated at King Hussein Cancer Center to understand clinical features and outcomes.
- The study included 53 patients aged 18 and older, with comprehensive assessments of disease characteristics and treatment responses over a median follow-up of 70 months, noting that 37.7% of patients died during this period.
- The findings highlighted significant correlations between patient outcomes and factors such as the extent of surgery and risk status, while molecular subgrouping did not predict survival outcomes, indicating a need for more aggressive treatment in high-risk patients.
Introduction: Most pediatric low-grade-gliomas (LGG) and some high-grade-gliomas (HGG) have alterations in the RAS/MAPK pathway. Promising high tumor response rates were achieved using BRAF/MEK inhibitors, however data on their use in low-middle-income-countries (LMICs) are limited.
Methods: We retrospectively reviewed our Jordanian experience of using compassionate BRAF/MEK inhibitors in treating children with gliomas.
Article Synopsis
- Dengue fever, caused by the dengue virus, is a major public health issue in Nigeria, with recent outbreaks highlighting its endemic nature and significant impact, including over 5 million cases and 5000 deaths in 2023.
- The paper focuses on the epidemiology of dengue in northern Nigeria, particularly in Sokoto state, and evaluates the Takeda dengue vaccine (TDV) and its potential to prevent the disease, despite challenges like vaccine acceptance and accessibility.
- To combat the spread of dengue, future strategies should involve government action, community engagement, and innovative control measures that address the factors contributing to outbreaks, influenced by urbanization and local practices.