Modeling and analysis of dengue transmission in fuzzy-fractional framework: a hybrid residual power series approach.

The current manuscript presents a mathematical model of dengue fever transmission with an asymptomatic compartment to capture infection dynamics in the presence of uncertainty. The model is fuzzified using triangular fuzzy numbers (TFNs) approach. The obtained fuzzy-fractional dengue model is then solved and analyzed through fuzzy extension of modified residual power series algorithm, which utilizes residual power series along with Laplace transform.

Unraveling Hydration Shell Dynamics and Viscosity Effects Around Cyanamide Probes via 2D IR Spectroscopy.

Hydration dynamics and solvent viscosity play critical roles in the structure and function of biomolecules. An overwhelming body of evidence suggests that protein and membrane fluctuations are closely linked to solvent fluctuations. While extensive research exists on the use of vibrational probes to detect local interactions and solvent dynamics, fewer studies have explored how the behavior of these reporters changes in response to bulk viscosity.

Determination of 31 Antimicrobials in Human Serum Using Ultra-High Performance Liquid Chromatography With Diode Array Detection for Application in Therapeutic Drug Monitoring.

Background: A versatile ultra-high performance liquid chromatography method with diode array detection was developed to quantify a wide range of antibiotics in human serum. This method addresses the need for rapid and accurate determination of antibiotic levels to ensure effective patient treatment and support the fight against antibiotic resistance.

Methods: This method assesses 31 different compounds covering β-lactams, fluoroquinolones, antifungals, antituberculars, and more.

Case report: Ectopic pregnancy at the level of broad ligament: A case report.

Introduction: Ectopic pregnancies are a significant clinical concern, with 90 % occurring in the fallopian tubes. However, they can also manifest in other locations, including the cervix, ovary, and abdominal cavity. Abdominal pregnancies, which constitute less than 1 % of ectopic pregnancies, are associated with considerable morbidity and mortality.

A simulation study to assess the influence of population pharmacokinetic model selection on initial dosing recommendations of vancomycin in neonates.

Aims: The accuracy of model-informed precision dosing largely depends on selecting the most appropriate population pharmacokinetic (popPK) model from many available options. This study aims to evaluate the concordance of optimal initial simulated doses among various vancomycin popPK models developed in neonates and to explore the role of predictive performance in explaining the variability in probability of target attainment (PTA).

Methods: A virtual neonatal patient population was created and 26 previously externally evaluated vancomycin popPK models were used to simulate 5 different dosing regimens.