Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson's disease.

The pathogenesis of Lewy body diseases (LBDs), including Parkinson's disease (PD), involves α-synuclein (α-Syn) aggregation that originates in peripheral organs and spreads to the brain. PD incidence is increased in individuals with chronic renal failure, but the underlying mechanisms remain unknown. Here we observed α-Syn deposits in the kidneys of patients with LBDs and in the kidney and central nervous system of individuals with end-stage renal disease without documented LBDs.

Freshwater Salinization Mitigated NO Emissions in Submerged Plant-Covered Systems: Insights from Attached Biofilms.

Submerged plants (SMPs) play a critical role in improving water quality and reducing NO greenhouse gas emissions. However, freshwater salinization represents a major environmental challenge in aquatic systems. To investigate the impact of salinization on NO emissions, this study conducted indoor mesocosm experiments simulating SMP and nonsubmerged plant (Non_SMP) areas in freshwater lakes.

Revealing differences in flavor compounds during plum wine fermentation using single and mixed yeast strains through metabolomic analysis.

Mixed fermentation can enhance the flavor and aroma of fruit wine, but the mechanisms driving this enhancement remain unclear. This study used non-targeted metabolomics to analyze the effects of mixed versus single fermentation on plum wine flavor. The results showed that compared with single fermentation, mixed fermentation reduced ethanol content and the ability to consume reducing sugars.

Efficacy of radiotherapy in treating local recurrence concomitant with distant metastasis of nasopharyngeal carcinoma: a long-term retrospective multicenter study.

Purpose: Patients with nasopharyngeal carcinoma (NPC) experiencing locoregional recurrence concomitant with distant metastases (rmNPC) after initial treatment represent a unique subgroup with significant management challenges. This study aimed to evaluate overall survival (OS) in rmNPC patients treated with systemic therapies with or without radiotherapy.

Methods: This retrospective multicenter study included patients with locally recurrent and metastatic NPC from five hospitals.

Revisiting the in-plane and in-channel diffusion of lithium ions in a solid-state electrolyte at room temperature through neural network-assisted molecular dynamics simulations.

Developing superionic conductor (SIC) materials offers a promising pathway to achieving high ionic conductivity in solid-state electrolytes (SSEs). The LiGePS (LGPS) family has received significant attention due to its remarkable ionic conductivity among various SIC materials. molecular dynamics (AIMD) simulations have been extensively used to explore the diffusion behavior of Li ions in LiGePS.