U-Pb zircon geochronology and geochemistry of Luk Ulo River boulders belong to Late Cretaceous-Paleocene metapsammite and metagranite of Luk Ulo Karangsambung, Central Java, Indonesia.

The rock formation of late Cretaceous-Paleocene metapsammite and metagranite found across Luk Ulo Complex indicated boulders with diameter of approximately 1 m and rounded shape along Luk Ulo River, Indonesia. However, less research found on geochronology and geochemistry has been conducted in study area, and such rocks require comprehensive understanding of magmatism and tectonic environment of Central Java, Indonesia. Therefore, the main objective of this study is to address the geochemical and geochronological age histories across Central Java, Indonesia, using U-Pb zircon dating technique.

supplementation reduces MDA, TNF-α, and IL-6 levels in a rat model exposed to soot particulates.

Background: Particulate matter (PM) is one of the important components in air pollution that can cause endothelial vascular dysfunction through exacerbation of atherosclerosis and inflammation of the respiratory system. Increased levels of malondialdehyde (MDA) in blood plasma can be an indicator of oxidative stress. Then, macrophages can secrete proinflammatory cytokines that will stimulate immune cells and vascular endothelial cells to release inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrotic factor-α (TNF-α).

Metal chloride anion based ionic liquids: synthesis, characterization and evaluation of performance in hydrogen sulfide oxidative absorption.

Three metal chloride anion based ionic liquids (MCABILs) were synthesized and characterized for high conversion of hydrogen sulfide (HS). The MCABILs were synthesized metathesis reaction and characterized by chemical spectroscopy such as FTIR, UV-Vis and CHNS elemental analysis. Then, the performance of those ionic liquids in HS conversion was evaluated at various temperatures and atmospheric pressure.

Designing siRNA/chitosan-methacrylate complex nanolipogel for prolonged gene silencing effects.

Despite immense revolutionary therapeutics potential, sustaining release of active small interfering RNA (siRNA) remains an arduous challenge. The development of nanoparticles with siRNA sustained release capabilities provides an avenue to enhance the therapeutic efficacy of gene-based therapy. Herein, we present a new system based on the encapsulation of siRNA/chitosan-methacrylate (CMA) complexes into liposomes to form UV crosslinkable Nanolipogels (NLGs) with sustained siRNA-release properties in vitro.

Analysis of matrix metalloproteinase-9 levels among acute heart failure patients with ACE inhibitor therapy (Dr. Soetomo Regional General Hospital, Surabaya).

Objectives: Heart disease is a clinical condition characterized by specific signs such as joint inflammation, weakness, and shortness of breath. Left ventricular remodeling can be experienced by patients with heart failure wherein a change in myocyte and nonmyocyte components occurs. One of the biomarkers in heart disease with myocardial fibrosis is matrix metalloproteinase-9 (MMP-9).