Optical soliton solutions of the M-fractional paraxial wave equation.

This research used a modified and extended auxiliary mapping method to examine the optical soliton solutions of the truncated time M-fractional paraxial wave equation. We employed the truncated time M-fractional derivative to eliminate the fractional order in the governing model. The few optical wave examples of the paraxial wave condition can assume an insignificant part in depicting the elements of optical soliton arrangements in optics and photonics for the investigation of different actual cycles, including the engendering of light through optical frameworks like focal points, mirrors, and fiber optics.

Water, sanitation, handwashing, and nutritional interventions can reduce child antibiotic use: evidence from Bangladesh and Kenya.

Antibiotics can trigger antimicrobial resistance and microbiome alterations. Reducing pathogen exposure and undernutrition can reduce infections and antibiotic use. We assess effects of water, sanitation, handwashing (WSH) and nutrition interventions on caregiver-reported antibiotic use in Bangladesh and Kenya, longitudinally measured at three timepoints among birth cohorts (ages 3-28 months) in a cluster-randomized trial.

Development and use of DJ-1 affinity microcolumns to screen and study small drug candidates for Parkinson's disease.

Background: DJ-1 is a protein whose mutation causes rare heritable forms of Parkinson's disease (PD) and is of interest as a target for treating PD and other disorders. This work used high performance affinity microcolumns to screen and examine the binding of small molecules to DJ-1, as could be used to develop new therapeutics or to study the role of DJ-1 in PD. Non-covalent entrapment was used to place microgram quantities of DJ-1 in an unmodified form within microcolumns, which were then used in multiple studies to analyze binding by model compounds and possible drug candidates to DJ-1.

Impacts of Ramadan fasting during pregnancy on pregnancy and birth outcomes: An umbrella review.

Background: Despite a large number of primary research studies, and systematic and narrative reviews, there is no consensus on the impact of fasting during Ramadan while pregnant on pregnancy and birth outcomes. Currently, there is no evidence-based guideline for Muslim women regarding Ramadan fasting during pregnancy and clinicians cannot provide firm recommendations.

Objectives: To review the current evidence regarding the impact of Ramadan fasting during pregnancy on pregnancy and birth outcomes.

Unraveling the interplay between cardiovascular diseases and alcohol use disorder: A bioinformatics and network-based exploration of shared molecular pathways and key biomarkers validation via western blot analysis.

Clinical observations indicate a pronounced exacerbation of Cardiovascular Diseases (CVDs) in individuals grappling with Alcohol Use Disorder (AUD), suggesting an intricate interplay between these maladies. Pinpointing shared risk factors for both conditions has proven elusive. To address this, we pioneered a sophisticated bioinformatics framework and network-based strategy to unearth genes exhibiting aberrant expression patterns in both AUD and CVDs.