Publications by authors named "M Xercavins"
Article Synopsis
- The study investigates the effectiveness of remdesivir on reducing mortality in COVID-19 patients, focusing on identifying specific patient groups that benefit the most from the treatment.
- Researchers analyzed data from 1160 hospitalized patients, identifying five distinct clusters based on factors like symptoms duration and lymphocyte counts, which revealed varying mortality rates among these groups.
- The findings suggest that patients with higher viral loads—characterized by lower lymphocyte counts and shorter symptom duration—showed significant mortality improvement when treated with remdesivir, validating these results in a separate patient cohort.
Background: Pneumococcal community-acquired pneumonia (P-CAP) is a major cause of morbidity and hospitalization. Several host genetics factors influencing risk of pneumococcal disease have been identified, with less information about its association with P-CAP. The aim of the study was to assess the influence of single nucleotide polymorphisms (SNP) within key genes involved in the innate immune response on the susceptibility to P-CAP and to study whether these polymorphic variants were associated with the severity and outcome of the episodes in a cohort of adult Caucasian patients.
View Article and Find Full Text PDFSignificant increase of CTX-M-15-ST131 and emergence of CTX-M-27-ST131 Escherichia coli high-risk clones causing healthcare-associated bacteraemia of urinary origin in Spain (ITUBRAS-2 project).
J Antimicrob Chemother
September 2023
Objectives: To assess the microbiological characteristics of Escherichia coli causing healthcare-associated bacteraemia of urinary origin (HCA-BUO) in Spain (ITUBRAS-2 project), with particular focus on ESBL producers and isolates belonging to ST131 high-risk clone (HiRC). Clinical characteristics and outcomes associated with ST131 infection were investigated.
Methods: A total of 222 E.
Bloodstream infections (BSI) are a major cause of mortality all over the world. Inappropriate empirical antimicrobial treatment (i-EAT) impact on mortality has been largely reported. However, information on related factors for the election of i-EAT in the treatment of BSI in adults is lacking.
View Article and Find Full Text PDFBackground: Febrile urinary tract infections (fUTI) in men are frequently complicated with subclinical prostatic involvement, measured by a transient increase in serum prostate-specific-antigen (sPSA). The aim of this study was to evaluate recurrence rates in a 6-month follow-up period of 2-week versus 4-week antibiotic treatment in men with fUTI, based on prostatic involvement. Clinical and microbiological cure rates at the end-of-therapy (EoT) were also assessed.
View Article and Find Full Text PDF