A general tribo-dynamic model for lubricated clearance joints in spatial multibody systems.

Existing tribo-dynamic models encounter challenges in accurately characterizing the intense coupling and notable nonlinearity between component deformation and oil film pressure in lubricated clearance joints. Consequently, a novel general tribo-dynamic coupling model based on an absolute coordinate framework has been developed in this paper. The equations of motion for flexible multibody systems are formulated based on the absolute nodal coordinate formulation.

NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis.

Background: Emerging evidence has revealed that PKM2 has oncogenic functions independent of its canonical pyruvate kinase activity, serving as a protein kinase that regulates gene expression. However, the mechanism by which PKM2, as a histone kinase, regulates the transcription of genes involved in triple-negative breast cancer (TNBC) metastasis remains poorly understood.

Methods: We integrated cellular analysis, including cell viability, proliferation, colony formation, and migration assays; biochemical assays, including protein interaction studies and ChIP; clinical sample analysis; RNA-Seq and CUT&Tag data; and xenograft or mammary-specific gene knockout mouse models, to investigate the epigenetic modulation of TNBC metastasis via NONO-dependent interactions with nuclear PKM2.

Hypoxia inducible factor-1α drives cancer resistance to cuproptosis.

Cuproptosis represents a new type of cell death that intricately associated with copper homeostasis and protein lipoylation. The cuproptosis suppression has been characterized in the hypoxic tumor microenvironment (TME). Here we reveal that hypoxia inducible factor-1α (HIF-1α) is a driver of cuproptosis resistance in solid tumor.

Cardiac Organoid Model Inspired Micro-Robot Smart Patch to Treat Myocardial Infarction.

Post-myocardial infarction (MI), the rapid decrease in pH triggers myocardial cell acidosis, which compromises the therapeutic efficacy of exosomes in MI. The groundbreaking research in the human cardiac organoid MI model suggests that exosomes, when paired with pH adjustment, dramatically reduce cardiomyocyte mortality while maintaining their proliferative potential, underscoring the importance of pH regulation in myocardial preservation. Micro-robot mounted micro-needle (MN) patch is thus proposed, targeting MI-acidic microenvironmet, to deliver exosomes into deep injured tissue.

Hepatocellular Carcinoma Screening: From Current Standard of Care to Future Directions.

Hepatocellular carcinoma (HCC) represents a significant portion of global cancer incidence and mortality. Screening with ultrasound with or without alpha-fetoprotein is recommended for those at high-risk. Although screening can lead to earlier treatment and better outcomes, existing screening paradigms have several flaws.