Resistance training protects the hippocampus and precuneus against atrophy and benefits white matter integrity in older adults with mild cognitive impairment.

Mild cognitive impairment (MCI) refers to cognitive alterations with preservation of functionality. Individuals with this diagnosis have a higher risk of developing dementia. Non-pharmacological interventions, such as physical exercise, are beneficial for the cognition of this population.

High-resolution genomic history of early medieval Europe.

Many known and unknown historical events have remained below detection thresholds of genetic studies because subtle ancestry changes are challenging to reconstruct. Methods based on shared haplotypes and rare variants improve power but are not explicitly temporal and have not been possible to adopt in unbiased ancestry models. Here we develop Twigstats, an approach of time-stratified ancestry analysis that can improve statistical power by an order of magnitude by focusing on coalescences in recent times, while remaining unbiased by population-specific drift.

Gerbils without Borders: Invasiveness, Plague, and Micro-Global Histories of Science, 1932-1939.

In the 1930s, a series of bubonic plague outbreaks among humans cropped up in several villages at the border of Angola and Namibia. These outbreaks provoked deep concern, laying bare social and political tensions amongst neighboring imperial powers and Indigenous people within the region. Despite the appearance of this disease in what was then considered a recondite place, its spread sparked debate in transnational forums, such as the League of Nations and the Office International d'Hygiène Publique.

Adoption of Digital Therapeutics in Europe.

Digital therapeutics (DTx) are an emerging medical therapy comprising evidence-based interventions that are regulatory approved for patient use, or are under development, for a variety of medical conditions, including hypertension, cancer, substance use disorders and mental disorders. DTx have significant potential to reduce the overall burden on healthcare systems and offer potential economic benefits. There is currently no specific legal regulation on DTx in the EU.

Relapsing Polychondritis Presenting With Hoarseness and Multisystem Involvement: A Diagnostic and Therapeutic Challenge.

Relapsing polychondritis (RP) is a rare autoimmune disorder characterized by recurrent inflammation of cartilaginous tissues throughout the body, particularly the ears, nose, eyes, joints, and the respiratory tract. We present a case of a 68-year-old female without previous comorbidities who presented with gradually progressive hoarseness of voice and inflammatory polyarthritis, nasal and ear involvement eventually leading to the diagnosis of RP with concurrent osteoporosis. The diagnosis was made based on Modified McAdam criteria, highlighting the significance of clinical evaluation in guiding diagnosis and treatment decisions.