Publications by authors named "M X Shanahan"
The most common somatic alteration in primary prostate cancer is the TMPRSS2:ERG gene fusion, which may be caused or promoted by distinct etiologic factors. The objective of this systematic review was to assess epidemiologic evidence on etiologic factors for prostate cancer by tumor TMPRSS2:ERG fusion status in human populations. Of 3071 publications identified, 19 cohort or case-control studies from six distinct study populations were included in this systematic review.
View Article and Find Full Text PDFBackground: The management of chronic non-cancer pain (CNCP) is complex. Concerns about adverse effects associated with opioid pain medications and a lack of funding for holistic programs present challenges for decision-making among clinicians and patients. Discrete choice experiments (DCE) are one way of assessing and valuing patient treatment preferences.
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- * Interviews were conducted with 12 mothers from low socioeconomic backgrounds, highlighting that barriers to maternal presence are largely societal and institutional, while facilitators depend on personal and interpersonal circumstances.
- * Recommendations for hospitals include offering free or low-cost sibling support, reducing parking fees, and providing clear communication about available resources to help families during their hospital stays.
Treatment options for non-small cell lung cancer (NSCLC) are evolving, given recent and expected approvals of immune checkpoint inhibitors (ICIs) targeting programmed cell death-(ligand) 1 (PD-1/PD-L1). We retrospectively evaluated outcomes among patients with resected stage IB-IIIA NSCLC tumors expressing PD-L1 using PALEOS (Pan-cAnadian Lung cancEr Observational Study) data (2016-2019). Key outcomes included PD-L1 expression rate and treatment patterns, recurrence, and median overall (mOS) and disease-free survival (mDFS) among PD-L1+ patients.
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- The study investigates how factors like race and socioeconomic status affect maternal presence in the Neonatal Intensive Care Unit (NICU), with a focus on mothers of Black infants.
- It finds that Medicaid status significantly predicts lower maternal presence rates, particularly among mothers with lower socioeconomic status.
- The authors suggest that interventions must target the resource-related challenges faced by low-SES mothers to improve their ability to be present in the NICU.