Publications by authors named "M Wynne"
Article Synopsis
- Partial cystectomy (PC) can be beneficial for some patients with muscle-invasive bladder cancer (MIBC), but its effectiveness may be limited if standard treatments like neoadjuvant chemotherapy (NAC) and pelvic lymph node dissection (PLND) aren’t used.
- A study involving 2,832 patients found that those who received NAC with PLND had significantly better overall survival (OS) compared to those treated with just PC, with median OS of 76.5 months for PLND only and not reached for the combination therapy.
- Factors such as private insurance, receiving NAC, and sufficient lymph node removal positively impacted OS, while older age, higher comorbidity index, and
Intralesional corticosteroid therapy (ICT) is a recommended management strategy for various inflammatory hair loss disorders. Pain from ICT can limit the use of this treatment, particularly in younger people and those with needle phobia. We present data demonstrating that vibration assisted analgesia, is a safe, effective and easy to use technique, which minimises pain from ICT, allowing its use in a wider cohort of patients.
View Article and Find Full Text PDFDuring adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC development is profoundly influenced by the social environment, disruptions to which may prime the emergence of psychopathology across the lifespan. We investigated the neurobehavioral consequences of isolation experienced in adolescence in mice, and in particular, the long-term consequences that were detectable even despite normalization of the social milieu.
View Article and Find Full Text PDFHow are human-specific brain bioenergetics and excitability connected? In this Neuron issue, Shen et al. reveal a human-specific interaction between RACK1 mRNA and FMRP. Reducing RACK1 mimics FMRP-dependent excitability and mitochondrial phenotypes, which can be reversed with mitochondrial-protective drugs.
View Article and Find Full Text PDFAim: To identify the optimal size metric and threshold for Prostate Imaging Reporting and Data System (PIRADS) 5 upgrade, calculate its positive predictive value (PPV) for clinically-significant prostate cancer (csPCA), and determine if it is indicative of a "very high" likelihood of csPCA.
Materials And Methods: One hundred and forty-three PIRADS 4 or 5 lesions were evaluated. Lesion diameters were used to calculate lesion volume (LV).