Publications by authors named "M Wolz"
Diagnostic and therapeutic challenges in PD-associated non-motor symptoms: the roles of neurologists and consultant physicians.
J Neural Transm (Vienna)
October 2024
In addition to their motor symptoms, almost all Parkinson's disease patients report non-motor symptoms (NMS) and, in the later course of the disease, non-motor fluctuations as well. These NMS encompass e.g.
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- Current estimates of genetic variants linked to Parkinson's disease (PD) show limitations and biases across different populations, complicating patient recruitment for clinical trials focused on genetic therapies.
- The Rostock Parkinson's disease (ROPAD) study analyzes data from 12,580 PD patients across 16 countries, revealing that 14.8% had a genetic test positive for PD-related variants, particularly in specific genes like GBA1 and LRRK2.
- Findings indicate higher positivity rates in patients with earlier onset (age ≤ 50) or a positive family history, emphasizing the need for more extensive genetic investigation to improve patient stratification for future clinical trials.
Background: As the most rapidly increasing neurodegenerative disease worldwide, Parkinson's disease is highly relevant to society. Successful treatment requires active patient participation. Patient education has been successfully implemented for many chronic diseases, such as diabetes and could also provide people with Parkinson's disease with skills to manage the disease better and to participate in shared decision making.
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- Advanced therapies (ATs) like deep brain stimulation and pump therapies are used for advanced Parkinson's disease but may lose effectiveness or cause side effects, necessitating changes or combinations of treatments.
- A nationwide study in Germany analyzed data from 22 centers to assess the effects and reasons for modifications in these ATs, using retrospective questionnaires to gather relevant clinical information since 2005.
- Results showed that 148 modifications across 116 patients led to significant improvements in symptom control and reduced side effects, with the main reasons for changes being inadequate symptom management and side effects from previous treatments.
Insects have a pivotal role in ecosystem function, thus the decline of more than 75% in insect biomass in protected areas over recent decades in Central Europe and elsewhere has alarmed the public, pushed decision-makers and stimulated research on insect population trends. However, the drivers of this decline are still not well understood. Here, we reanalysed 27 years of insect biomass data from Hallmann et al.
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