Publications by authors named "M Wirenfeldt"
Meningiomas are the most common primary central nervous system tumor. Clinical trials have failed to support effective medical treatments, despite initially promising animal studies. A key issue could be that available experimental models fail to mimic the clinical situation.
View Article and Find Full Text PDFWhite matter damage and subsequent demyelination significantly contribute to long-term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligodendrocytes may open new perspectives for ischaemic stroke treatment. In this respect, previous studies highlighted the role of the G protein-coupled membrane receptor 17 (GPR17) as a key regulator of OPC differentiation in experimental models of brain injury, including ischaemic stroke.
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- Differentiating between recurrent cerebral metastasis (CM) and brain radiation necrosis (BRN) is crucial for treatment decisions, but current imaging techniques struggle to make accurate distinctions.
- In a study analyzing 32 cases of cerebral metastases, conventional MRI accurately identified CM in only 75% of cases, while MR perfusion scans revealed higher blood volume in metastasis but couldn’t definitively differentiate the two conditions.
- The research highlights the need for histopathological examination for accurate diagnosis and suggests further studies to enhance non-invasive imaging techniques for better management of patients experiencing these complications.
Article Synopsis
- MEN1 is a rare genetic syndrome caused by mutations in the menin 1 gene, leading to tumors in multiple endocrine glands, particularly affecting parathyroid, pancreatic, and pituitary glands.
- Primary hyperparathyroidism is the most common manifestation, followed by pancreatic neuroendocrine tumors, and recent studies have identified ependymoma as another potential neoplasm associated with MEN1.
- The text introduces a new tumor subtype linked to MEN1 called Pleomorphic Xanthoastocytoma grade 3 differential pathology (PDP), suggesting that it may arise from specific genetic variants related to the MEN1 gene and associated factors.
Introduction: The purpose of this study was to determine if conjunctival lymphangiogenesis can be induced using adenoviral delivery of vascular endothelial growth factor C (VEGF-C).
Methods: Seventeen New Zealand white rabbits received a subconjunctival injection containing 3.5 × 107 plaque-forming units of an adenoviral vector containing the gene-encoding VEGF-C (Ad-VEGF-C).