Publications by authors named "M Winny"
Background And Aims: The enteric nervous system independently controls gastrointestinal function including motility, which is primarily mediated by the myenteric plexus, therefore also playing a crucial role in functional intestinal disorders. Live recordings from human myenteric neurons proved to be challenging due to technical difficulties. Using the neuroimaging technique, we are able to record human colonic myenteric neuronal activity and investigate their functional properties in a large cohort of patients.
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- The study tested the efficacy of four starch-based hemostats (4DryField PH, Arista AH, HaemoCer PLUS, and StarSil) for preventing peritoneal adhesion formation in a rat model.
- 4DryField PH was the only product that significantly reduced adhesion formation, while HaemoCer PLUS and StarSil showed no statistically significant effect.
- The findings suggest that not all starch-based hemostats are effective for adhesion prevention, casting doubt on their general capability in this regard.
Article Synopsis
- * It was found that most patients had tumor resections, with a median time to diagnose leakage of 10 days and median E-VAC therapy lasting 14 days; 83% of patients experienced closure or complete healing of their leaks.
- * High levels of C-reactive protein (CRP) were linked to poorer outcomes, as patients with CRP levels above 100 mg/L had a higher likelihood of unsuccessful stoma reversal and complications, including deaths mainly due to sepsis.
Basic processes of the fatty acid metabolism have an important impact on the function of intestinal epithelial cells (IEC). However, while the role of cellular fatty acid oxidation is well appreciated, it is not clear how de novo fatty acid synthesis (FAS) influences the biology of IECs. We report here that interfering with de novo FAS by deletion of the enzyme Acetyl-CoA-Carboxylase (ACC)1 in IECs results in the loss of epithelial crypt structures and a specific decline in Lgr5 intestinal epithelial stem cells (ISC).
View Article and Find Full Text PDFAdhesion barriers can be based on numerous substances. In the rat Optimized Peritoneal Adhesion Model (OPAM) the starch-based hemostats 4DryField and Arista were tested for their capability to act in a preventive manner against adhesion formation (applied as a powder that was mixed with saline solution to form a barrier gel). Adhesions were scored using the established scoring systems by Lauder and Hoffmann, as well as histopathologically using the score by Zühlke.
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