Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone.

Background & Aims: An optimal HCV vaccine requires the induction of antibodies that neutralise the infectivity of many heterogenous viral isolates. In this study, we have focused on determining the optimal recombinant envelope glycoprotein component to elicit cross-neutralising antibodies against global HCV genotypes. We compared the immunoreactivity and antigenicity of the HCV genotype 1a strain H77C-derived envelope glycoprotein heterodimer gpE1/gpE2 with that of recombinant gpE2 alone.

Efficacy and safety of implantable cardioverter-defibrillator implantation in the elderly-The I-70 Study: A randomized clinical trial.

Background: There is conflicting evidence on the efficacy of primary prevention implantable cardioverter-defibrillator (ICD) implantation in the elderly.

Objective: The purpose of this study was to determine the efficacy and safety of ICD implantation in patients 70 years and older.

Methods: Patients (n = 167) aged 70 years or older and eligible for ICD implantation were randomly assigned (1:1) to receive either optimal medical therapy (OMT) (n = 85) or OMT plus ICD (n = 82).

Letter From Vienna.

The EPF 35th Annual Conference will be held in Vienna in July 2022 after it was postponed in 2020 due to the pandemic. All the greater is the pleasure to welcome you to the EPF Congress with the theme of Ideals this summer. The Vienna Psychoanalytical Society (WPV, Wiener Psychoanalytische Vereinigung) and the Vienna Psychoanalytical Association (WAP, Wiener Arbeitskreis für Psychoanalyse) would like to extend a warm invitation and welcome to Vienna, the birthplace of Psychoanalysis.