Publications by authors named "M Willner"
Article Synopsis
- Multimodal monitoring combines data from various sensors to improve patient care, particularly for traumatic brain injury cases, and the study aims to implement this in battlefield scenarios using a noninvasive approach and AI-based guidance.
- A Value-Burden Analysis was created to assess the effectiveness and deployment challenges of different sensors, ultimately scoring 17 sensors to find the best fit for military use.
- The resulting system is modular with a comprehensive Knowledge Base, allowing it to provide guidance consistent with existing clinical guidelines while demonstrating feasibility in a prototype test.
Article Synopsis
- Long-term opioid exposure, particularly among pregnant mothers, negatively affects the embryonic brain, but researching this has been challenging due to limited access to human brains and differences in animal models.
- Researchers developed a human midbrain model using stem cells to study the effects of acute and chronic fentanyl treatment and withdrawal on brain development.
- Findings show that chronic exposure hinders proper neuronal development, while acute exposure temporarily boosts dopamine release without major changes in gene expression regarding cell development, marking a first-of-its-kind analysis at the single-cell level for human midbrain development.
The opening of the blood-brain barrier (BBB) by focused ultrasound (FUS) coupled with intravenously injected microbubbles can be leveraged as a form of immunotherapy for the treatment of neurodegenerative disorders. However, how FUS BBB opening affects brain macrophages is not well understood. Here by using single-cell sequencing to characterize the distinct responses of microglia and central nervous system-associated macrophages (CAMs) to FUS-mediated BBB opening in mice, we show that the treatment remodels the immune landscape via the recruitment of CAMs and the proliferation of microglia and via population size increases in disease-associated microglia.
View Article and Find Full Text PDFBackground: The differentiation of minimal-fat-or low-fat-angiomyolipomas from other renal lesions is clinically challenging in conventional computed tomography. In this work, we have assessed the potential of grating-based x-ray phase-contrast computed tomography (GBPC-CT) for visualization and quantitative differentiation of minimal-fat angiomyolipomas (mfAMLs) and oncocytomas from renal cell carcinomas (RCCs) on ex vivo renal samples.
Materials And Methods: Laboratory GBPC-CT was performed at 40 kVp on 28 ex vivo kidney specimens including five angiomyolipomas with three minimal-fat (mfAMLs) and two high-fat (hfAMLs) subtypes as well as three oncocytomas and 20 RCCs with eight clear cell (ccRCCs), seven papillary (pRCCs) and five chromophobe RCC (chrRCC) subtypes.
Wood decomposition is a central process contributing to global carbon and nutrient cycling. Quantifying the role of the major biotic agents of wood decomposition, i.e.
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