Publications by authors named "M Willig"
Evidence suggests that bats are important hosts of filoviruses, yet the specific species involved remain largely unidentified. Niemann-Pick C1 (NPC1) is an essential entry receptor, with amino acid variations influencing viral susceptibility and species-specific tropism. Herein, we conducted combinatorial binding studies with seven filovirus glycoproteins (GPs) and NPC1 orthologs from 81 bat species.
View Article and Find Full Text PDFBackground: To reduce the number of deaths caused by exsanguination, the initial management of severe trauma aims to prevent, if not limit, the lethal triad, which consists of acidosis, coagulopathy, and hypothermia. Recently, several studies have suggested adding hypocalcemia to the lethal triad to form the lethal diamond, but the evidence supporting this change is limited. Therefore, the aim of this study was to compare the lethal triad and lethal diamond for their respective associations with 24-h mortality in severe trauma patients receiving transfusion.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the experiences of ICU healthcare professionals regarding controlled donation after circulatory death (cDCD), amid ethical concerns between end-of-life care and organ donation.
- Conducted in 32 ICUs in France, the study surveyed 206 physicians and nurses after the deaths of patients considered potential cDCD donors, measuring their anxiety levels and feelings of tension related to the donation process.
- Results show that cDCD does not significantly increase anxiety for healthcare professionals compared to regular end-of-life situations, with a general positive perception of cDCD among them, suggesting a need for better support in balancing life support decisions and organ donation.
Article Synopsis
- The study focuses on the rising aging population in France and Western Europe, specifically individuals aged 85 and older, and their mortality risk in trauma centers' ICUs.
- Conducted from 2013 to 2022, the research analyzed 365 severely injured older patients in 14 ICU trauma centers, assessing their frailty and other clinical variables.
- High mortality rates were found, with 43.5% in the ICU and 45.5% at 30 days, linked to factors like traumatic brain injury and severe hemorrhage, highlighting the need for early geriatric interventions to improve patient outcomes.
Article Synopsis
- Researchers are studying how viruses infect bats in Puerto Rico to learn more about viral epidemics and improve public health.
- They collected samples from 1086 bats and found a lot of different herpesviruses, which they categorized into groups for further study.
- The results showed that most herpesviruses prefer to infect just one type of bat rather than spreading to many different species, and they explained how this can help us understand virus communities better.