Publications by authors named "M Willenborg"
Assess for continued improvements in patient outcomes after updating our institutional sedation and analgesia protocol to include recommendations from the 2013 Society of Critical Care Medicine (SCCM) Pain, Agitation, and Delirium (PAD) guidelines. Retrospective before-and-after study in a mixed medical/surgical intensive care unit (ICU) at an academic medical center. Mechanically ventilated adults admitted from September 1, 2011 through August 31, 2012 (pre-implementation) and October 1, 2012 through September 30, 2017 (post-implementation) were included.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the interactions between major pathogens in pigs, focusing on their role in respiratory diseases and co-infections, specifically in the context of the porcine respiratory disease complex (PRDC).
- The researchers created a precision-cut lung slice (PCLS) model to examine how an initial infection affects subsequent pathogen adherence, colonization, and cytotoxicity.
- Findings suggest that pre-infection with one pathogen enhances the ability of a second pathogen to adhere and colonize, largely due to the reduction of ciliary activity, and highlights the importance of a specific toxin (suilysin) in this cytotoxic process.
() is a major cause of economic losses in the pig industry worldwide and is an emerging zoonotic pathogen. One important virulence-associated factor is suilysin (SLY), a toxin that belongs to the family of cholesterol-dependent pore-forming cytolysins (CDC). However, the precise role of SLY in host-pathogen interactions is still unclear.
View Article and Find Full Text PDFis an important zoonotic pathogen which can infect humans and pigs worldwide, posing a potential risk to global public health. Suilysin, a pore-forming cholesterol-dependent cytolysin, is considered to play an important role in the pathogenesis of infections. It is known that infection with influenza A viruses may favor susceptibility to secondary bacterial infection, resulting in more severe disease and increased mortality.
View Article and Find Full Text PDFStreptococcus suis is a swine pathogen and zoonotic agent responsible for meningitis and septic shock. Although several putative virulence factors have been described, the initial steps of the S. suis pathogenesis remain poorly understood.
View Article and Find Full Text PDF