Publications by authors named "M Wijnen"

Background: The 5-year prognosis of non-high-risk neuroblastomas is generally good (>90%). However, a proportion of patients show progression and succumb to their disease. We aimed to identify molecular aberrations (not incorporated in the current risk stratification) associated with overall survival (OS) and/or event-free survival (EFS) in patients diagnosed with non-high-risk neuroblastoma.

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Background And Aim: In this retrospective single center cohort study, we report the surgical outcomes of nephron-sparing surgery (NSS) for Wilms' tumor (WT) patients since centralization of pediatric oncology care in the Netherlands, and implementation of technological advancements. Therewith we describe the influence of experience and innovations for this type of surgery.

Methods: We retrospectively assessed all NSS procedures from January 1st 2015 until January 1st 2024 for patients who underwent surgery for a renal tumor at the Princess Máxima Center for Pediatric Oncology.

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A defect in the canonical Wnt-β-catenin pathway may lead to reduced bone strength and increased fracture risk. Sclerostin is a key inhibitor of this pathway by binding to low-density lipoprotein (LDL) receptor-related protein , thereby reducing bone formation. The effectiveness of romosozumab, a human monoclonal antibody that binds sclerostin and prevents this inhibitory effect, has been questioned in patients with inactivating genetic variants in or .

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Purpose: Participation in everyday life activities is important for the development of children and is an important topic in rehabilitation practices. This qualitative study aimed to unveil the perspectives and experiences of teenagers with vision impairments (VIs) or motor impairments (MIs) regarding their participation in leisure activities.

Materials And Methods: 13 teenagers with VIs and 12 teenagers with MIs (age range: 11-15 years) participated in this study.

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Article Synopsis
  • This study investigates the effectiveness of highly-conformal image-guided radiotherapy (IGRT) for patients with high-risk neuroblastoma (HR-NBL), focusing on locoregional control outcomes.
  • The research involved 77 patients treated between 2015-2022, analyzing various factors such as the size of residual lesions and their impact on locoregional failure rates.
  • Results showed a low five-year locoregional failure rate of 7.8%, indicating that IGRT with reduced margins and dose boosts for larger residual lesions is effective in managing HR-NBL.
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