Publications by authors named "M Wibowo"

Soil bacteria are prolific producers of a myriad of biologically active secondary metabolites. These natural products play key roles in modern society, finding use as anti-cancer agents, as food additives, and as alternatives to chemical pesticides. As for their original role in interbacterial communication, secondary metabolites have been extensively studied under in vitro conditions, revealing many roles including antagonism, effects on motility, niche colonization, signaling, and cellular differentiation.

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  • - This research focuses on green methods to react levofloxacin (LF) with various dicarboxylate acids, studying their effects on LF's stability, solubility, and antimicrobial effectiveness for the first time.
  • - The study utilized solvent-dropped grinding with 95% ethanol for preparation, significantly reducing solvent use compared to traditional methods, and confirmed the interaction between LF and the acids using techniques like FTIR and 1H-NMR.
  • - Results showed that the LF-dicarboxylate salts produced had improved solubility, stability, and antibacterial potency compared to LF alone, indicating promising potential for new drug formulations.
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Smoking is one of the risk factors for non-communicable diseases. Smoking worsens a person's health and can even cause death. This smoking behaviour is primarily initiated in adolescence.

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Previously characterized as inert fat depots, adipocytes are now recognized as dynamic mediators of inflammatory tone, metabolic health, and nutrient homeostasis. As endocrine organs, specialized depots of adipose tissue engage in crosstalk between the gut, liver, pancreas, and brain to coordinate appetite, thermogenesis, and ultimately body weight. These functions are tightly linked to the inflammatory status of adipose tissue, which is in turn influenced by the health of the gut microbiome.

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  • * Out of 155 examined cows, 61.9% showed reproductive issues due to FMD, with the most common problem being ovarian hypofunction (53.5%).
  • * Administering gonadotropin hormone-releasing hormone (GnRH) to affected cows resulted in a 98% recovery rate in reproductive performance, with improved conception and pregnancy rates.
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