Publications by authors named "M Whitby"
Article Synopsis
- Replication forks encountering unrepaired single-strand breaks (SSBs) can lead to both single-ended (seDSBs) and double-ended double-strand breaks (deDSBs), which are significant in cancer development.
- The study reveals that in fission yeast, SSBs typically result in deDSBs repaired by homologous recombination, but can also initiate break-induced replication (BIR).
- The occurrence of BIR is more frequent when DNA replication fork convergence is delayed and the Ku70 protein, involved in non-homologous end joining, is absent.
The world's rich diversity of bats supports healthy ecosystems and important ecosystem services. Maintaining healthy biological systems requires prompt identification of threats to biodiversity and immediate action to protect species, which for wide-ranging bat species that span geopolitical boundaries warrants international coordination. Anthropogenic forces drive the threats to bats throughout North America and the world.
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- Wind energy is increasing globally to cut greenhouse gas emissions, but it negatively affects bat populations due to turbine-related fatalities and habitat loss.
- Measures such as placing turbines away from sensitive areas and limiting operations during peak bat activity are essential to minimize these impacts.
- There is a lack of legal protections for bats against wind energy development in many countries, highlighting the need for governments and financial institutions to enforce environmental standards to balance energy production with wildlife conservation.
Replication fork stalling can provoke fork reversal to form a four-way DNA junction. This remodelling of the replication fork can facilitate repair, aid bypass of DNA lesions, and enable replication restart, but may also pose a risk of over-replication during fork convergence. We show that replication fork stalling at a site-specific barrier in fission yeast can induce gene duplication-deletion rearrangements that are independent of replication restart-associated template switching and Rad51-dependent multi-invasion.
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