Publications by authors named "M Whelan"
Introduction: To investigate the current evidence regarding long-term outcomes using laparoscopic peritoneal lavage (LPL) versus primary bowel resection (PR) in Hinchey III diverticulitis.
Methods: A systematic review was undertaken based upon articles published between 1st January 2000 and 1st March 2024. Databases Pubmed, Scopus and Embase were used employing the key search terms "diverticulitis" and "peritoneal lavage".
There is increasing interest in chemicals which are persistent, mobile and toxic (PMT), primarily to protect drinking water. We present a tiered assessment of drinking water exposure and associated human health risks for 22 PMT substances. Worst-case exposure via drinking water is assumed to occur when wastewater is discharged to rivers which are then abstracted for water supply.
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- COVID-19 is evolving from a pandemic to an endemic phase due to ongoing mutations, with initial research targeting its primary infection route via the spike protein and ACE2 receptor in lung cells.
- The virus also infects macrophages using an alternate entry point (NRP1), making it crucial to develop therapies that prevent this and help treat post-COVID complications.
- Out of over 33,000 compounds analyzed, five small molecule inhibitors were identified that effectively lower NRP1 expression in macrophages with minimal toxicity, showing promise for future therapeutic strategies against COVID-19.