Publications by authors named "M Wetzel"
J Neurooncol
December 2024
Article Synopsis
- The study investigates how multimodal treatment affects progression-free survival (PFS) and overall survival (OS) for patients with multiple localizations of glioblastoma, a rare and aggressive brain tumor.*
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- Researchers analyzed data from 483 glioblastoma patients, finding that the extent of surgical resection significantly predicts both PFS and OS, and that various treatment strategies improved outcomes.*
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- The results indicate that patients with multiple lesions can achieve similar survival rates as those with a single tumor when receiving aggressive, comprehensive treatment.*
Commun Med (Lond)
October 2024
Article Synopsis
- * A study of 445 PD patients revealed a higher diversity of microbes compared to 221 controls, with specific bacterial overabundances and depletions identified as key signatures of PD.
- * Findings indicate that certain oral microbiome characteristics could act as potential biomarkers for early PD detection, particularly in relation to non-motor symptoms linked to the peripheral nervous system.
Article Synopsis
- Pancreatic adenocarcinoma (PDAC) is a challenging cancer to treat with immunotherapies, but certain intratumoral structures called tertiary lymphoid structures (TLS) have been linked to better patient survival outcomes.
- A comprehensive study analyzed 26 PDAC tumors using advanced techniques like machine learning and spatial transcriptomics to better understand the role of TLS within tumors.
- The findings revealed specific gene expression patterns in TLS that correlate with improved survival, highlighting the importance of TLS maturation and its interactions with immune cells and the tumor environment.
GEN Biotechnol
December 2023
Article Synopsis
- Gene expression is influenced by epigenetics and varies based on the cellular environment, with recent advancements in spatial omics enhancing our understanding of this context.
- The introduction of DBiT-seq offers a pioneering method for spatial epigenomic profiling at the cellular level, significantly improving cell typing and identification of regulatory elements.
- The new 96-channel microfluidics chip provides more precise spatial mapping of brain cells, revealing the intricate organization of glial and neuronal cells and the regulatory mechanisms that affect development and disease.
