Niacin Ester Derivative of Brefeldin A as a Potential Dual-Target Arf1/BMX Inhibitor for Bladder Cancer.

Bladder cancer is a common malignancy known for its high recurrence rate and poor survival rate. New strategies are urgently needed to reduce recurrence and improve prognosis. Arf1 and BMX are potential targets associated with the prognosis of bladder cancer.

Efficacy and safety of L. combined with antithyroid drugs for hyperthyroidism: a systematic review and meta-analysis.

Objective: To systematically evaluate the efficacy and safety of L. (PVL) preparations combined with antithyroid drugs (ATDs) for the treatment of hyperthyroidism.

Methods: Eight Chinese and English databases were searched for randomized controlled trials (RCTs) comparing PVL preparations combined with ATDs and ATDs for hyperthyroidism treatment.

Migration characteristics and human health risk assessment of selenium and heavy metals in rhizosphere soil-crop system in high geological background area of southern Qinling Mountains: A case study of Shiquan County, Shaanxi, China.

Elevated heavy metal concentrations in selenium-enriched soils from high geological background areas raise concerns about crop safety and human health. This study investigates the migration characteristics and influencing factors of selenium and heavy metals in the rhizosphere soil-crop systems of the southern Qinling Mountains, with a focus on potential human health risks. Results revealed that selenium and heavy metal concentrations in rocks and rhizosphere soils exceeded local background values, with the highest exceedance ratios observed for chromium in rocks (48.

self-assembled peptide nanoparticles improve the anti-hepatic fibrosis effect.

Antagonistic peptide Leu-Ser-Lys-Leu (LSKL) is capable of blocking the transforming growth factor-β (TGF-β) signaling pathway and exhibits anti-fibrotic effects. Herein, we constructed LSKL nanoparticles (NPs) based on an alkaline phosphatase (ALP)-instructed self-assembly strategy for improving its specific therapeutic effect against liver fibrosis.