Publications by authors named "M Wehr"
Background: Homo- and heteromerization of G protein-coupled receptors (GPCRs) plays an important role in the regulation of receptor functions. Recently, we demonstrated an interaction between the serotonin receptor 7 (5-HT7R), a class A GPCR, and the cell adhesion molecule CD44. However, the functional consequences of this interaction on 5-HT7R-mediated signaling remained enigmatic.
View Article and Find Full Text PDFVertebrates sniff to control the odor samples that enter their nose. These samples can not only help identify odorous objects, but also locations and events. However, there is no receptor for place or time.
View Article and Find Full Text PDFSelectivity profiling is key for assessing the pharmacological properties of multi-target drugs. We have developed a cell-based and barcoded assay encompassing ten druggable targets, including G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs), nuclear receptors, a protease as well as their key downstream pathways and profiled 17 drugs in living cells for efficacy, potency, and side effects. Notably, this multiplex assay, termed safetyProfiler assay, enabled the simultaneous assessment of multiple target and pathway activities, shedding light on the polypharmacological profile of compounds.
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- Research shows an inverted-U relationship between arousal levels and decision-making performance in tasks involving sound discrimination, with optimal performance at moderate arousal.
- During the study, researchers recorded neural activity in the auditory cortex of mice while measuring their arousal through pupil size changes, linking this to how well the mice could discern tones.
- The findings suggest that this optimal performance occurs during a shift in brain activity patterns, where increased arousal leads to reduced variability in neural responses, offering insights into how arousal affects sensory processing and decision-making in the brain.
Next-generation risk assessment relies on mechanistic data from new approach methods, including transcriptome data. Various technologies, such as high-throughput targeted sequencing methods and microarray technologies based on hybridization with complementary probes, are used to determine differentially expressed genes (DEGs). The integration of data from different technologies requires a good understanding of the differences arising from the use of various technologies.
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