Publications by authors named "M Wansbrough-Jones"
Bacterial diversity in Buruli ulcer lesions in Ghana.
J Clin Tuberc Other Mycobact Dis
August 2024
Article Synopsis
- A study was conducted to explore how the variety of bacteria in Buruli ulcer lesions affects treatment outcome, focusing on cases in central Ghana.
- The researchers collected samples from 36 participants, finding that ulcers on the lower limbs had more bacterial diversity and that higher diversity was linked to poorer healing outcomes.
- The study suggests that the presence of diverse bacteria, including antibiotic-resistant strains, impacts recovery, highlighting the need for better treatment protocols to manage these infections.
Clinical and microbiological predictors of healing in Buruli ulcer disease.
J Clin Tuberc Other Mycobact Dis
February 2024
Introduction: Wound measurements are relevant in monitoring the rate of healing (RoH) and may predict time to healing. Predicting the time to healing can help improve the management of Buruli ulcer. We examine three methods for the determination of RoH and their use as predictors of time to healing.
View Article and Find Full Text PDFBackground: Previous studies have reported that presence and severity of Buruli ulcer (BU) may reflect the underlying immunosuppression in HIV infected individuals by causing increased incidence of multiple, larger and ulcerated lesions. We report cases of BU-HIV coinfection and the accompanying programmatic challenges encountered in central Ghana.
Methods: Patients with PCR confirmed BU in central Ghana who were HIV positive were identified and their BU01 forms were retrieved and reviewed in further detail.
Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial.
Lancet
April 2020
Background: Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans infection that damages the skin and subcutis. It is most prevalent in western and central Africa and Australia. Standard antimicrobial treatment with oral rifampicin 10 mg/kg plus intramuscular streptomycin 15 mg/kg once daily for 8 weeks (RS8) is highly effective, but streptomycin injections are painful and potentially harmful.
View Article and Find Full Text PDFBackground: We investigated the relationship between bacterial load in Buruli ulcer (BU) lesions and the development of paradoxical reaction following initiation of antibiotic treatment.
Methods: This was a longitudinal study involving BU patients from June 2013 to June 2017. Fine needle aspirates (FNA) and swab samples were obtained to establish the diagnosis of BU by PCR.