Personalized perioperative blood pressure management in patients having major non-cardiac surgery: A bicentric pilot randomized trial.

Study Objective: We hypothesize that personalized perioperative blood pressure management maintaining intraoperative mean arterial pressure (MAP) above the preoperative mean nighttime MAP reduces perfusion-related organ injury compared to maintaining intraoperative MAP above 65 mmHg in patients having major non-cardiac surgery. Before testing this hypothesis in a large-scale trial, we performed this bicentric pilot trial to determine a) if performing preoperative automated nighttime blood pressure monitoring to calculate personalized intraoperative MAP targets is feasible; b) in what proportion of patients the preoperative mean nighttime MAP clinically meaningfully differs from a MAP of 65 mmHg; and c) if maintaining intraoperative MAP above the preoperative mean nighttime MAP is feasible in patients having major non-cardiac surgery.

Design: Bicentric pilot randomized trial.

Beyond the information (not) given: Associative mechanisms versus representations of uncertainty in extinction in laboratory rats (Rattus norvegicus).

Associative learning models typically reflect statistical relationships between experienced events. Causal models can go beyond this information to specify the ways in which events are related. This meta-representational aspect of causal models allows them to reflect uncertainty about relationships between events: for example, if a light initially leads to sucrose but subsequently the light is experienced without sucrose, this might first support formation of a light-causes-sucrose model and subsequently lead to uncertainty over whether the model remained accurate.

Release kinetics of growth factors loaded into β-TCP ceramics in an model.

Introduction: β-TCP ceramics are bone replacement materials that have recently been tested as a drug delivery system that can potentially be applied to endogenous substances like growth factors found in blood platelets to facilitate positive attributes.

Methods: In this work, we used flow chamber loading to load β-TCP dowels with blood suspensions of platelet-rich plasma (PRP), platelet-poor plasma (PPP), or buffy coat (BC) character. PRP and BC platelet counts were adjusted to the same level by dilution.

Analysis of polyphosphate in mammalian cells and tissues: methods, functions and challenges.

Polyphosphates play a crucial role in various biological processes, such as blood coagulation, energy homeostasis, and cellular stress response. However, their isolation, detection, and quantification present significant challenges. These difficulties arise primarily from their solubility, low concentration in mammals, and structural similarity to other ubiquitous biopolymers.

An Update on Polyphosphate In Vivo Activities.

Polyphosphate (polyP) is an evolutionary ancient inorganic molecule widespread in biology, exerting a broad range of biological activities. The intracellular polymer serves as an energy storage pool and phosphate/calcium ion reservoir with implications for basal cellular functions. Metabolisms of the polymer are well understood in procaryotes and unicellular eukaryotic cells.