Executioner caspases degrade essential mediators of pathogen-host interactions to inhibit growth of intracellular Listeria monocytogenes.

Cell death mediated by executioner caspases is essential during organ development and for organismal homeostasis. The mechanistic role of activated executioner caspases in antibacterial defense during infections with intracellular bacteria, such as Listeria monocytogenes, remains elusive. Cell death upon intracellular bacterial infections is considered altruistic to deprive the pathogens of their protective niche.

Does Orkish Sound Evil? Perception of Fantasy Languages and Their Phonetic and Phonological Characteristics.

Constructed languages, frequently invented to support world-building in fantasy and science fiction genres, are often intended to sound similar to the characteristics of the people who speak them. The aims of this study are (1) to investigate whether some fictional languages, such as Orkish whose speakers are portrayed as villainous, are rated more negatively by listeners than, for example, the Elvish languages, even when they are all produced without emotional involvement in the voice; and (2) to investigate whether the rating results can be related to the sound structure of the languages under investigation. An online rating experiment with three 7-point semantic differential scales was conducted, in which three sentences from each of 12 fictional languages (Neo-Orkish, Quenya, Sindarin, Khuzdul, Adûnaic, Klingon, Vulcan, Atlantean, Dothraki, Na'vi, Kesh, ʕuiʕuid) were rated, spoken by a female and a male speaker.

Biocompatible Rhamnolipid Self-Assemblies with pH-Responsive Antimicrobial Activity.

There is an urgent need for alternative antimicrobial materials due to the growing challenge of bacteria becoming resistant to conventional antibiotics. This study demonstrates the creation of a biocompatible pH-switchable antimicrobial material by combining bacteria-derived rhamnolipids (RL) and food-grade glycerol monooleate (GMO). The integration of RL into dispersed GMO particles, with an inverse-type liquid crystalline cubic structure in the core, leads to colloidally stable supramolecular materials.

Feasibility and Acceptability of an Online Yoga Study Among Individuals with Irritable Bowel Syndrome (IBS).

Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain that is often comorbid with psychiatric disorders and other pain-related conditions. The practice of yoga improves symptoms among patients with IBS, although the virtual delivery of yoga in this patient population remains understudied. The purpose of this article is to report feasibility and acceptability of a 6-week pilot yoga intervention among IBS and healthy control participants, which was transitioned to an online format in response to the COVID-19 pandemic.