Publications by authors named "M W Weyer"
Article Synopsis
- Progranulin (PGRN) is a neurotrophic and anti-inflammatory protein, and its loss due to human mutations is linked to frontotemporal dementia, with PGRN knockout (KO) mice used to model this condition.
- Restoration of PGRN in neurons (but not microglia) was achieved in a specific mouse model, allowing researchers to investigate if it could reduce brain damage after traumatic brain injury (TBI).
- Findings indicated that restoring PGRN in neurons was enough to mitigate excessive brain damage caused by TBI, suggesting that microglial PGRN was not necessary for neuroprotection and anti-inflammatory effects in this context.
Article Synopsis
- The study investigates the relationship between poorly controlled type 1 diabetes (T1D) and elevated liver enzyme levels (ALT) in children and adolescents, suggesting a link to metabolic dysfunction associated steatotic liver disease (MASLD).
- Researchers analyzed data from over 32,000 young patients with T1D from Germany, Austria, and Switzerland, using statistical models to identify associations over time.
- Results indicated that children with poorly managed T1D had significantly higher odds of elevated ALT levels, highlighting the importance of effective diabetes management in reducing the risk of MASLD.
Seaweed is becoming increasingly popular in the Western diet as consumers opt for more sustainable food sources. However, seaweed is known to accumulate high levels of arsenic-which may be in the form of carcinogenic inorganic arsenic (iAs). Here we propose a fast method for the routine measurement of iAs in seaweed using HPLC-ICP-MS without coelution of arsenosugars that may complicate quantification.
View Article and Find Full Text PDFPurpose: The purpose of the study was to report the clinical, functional and radiological outcome following varus osteotomy as a salvage procedure in young to middle-aged patients with patellofemoral arthritis (PFA) and associated valgus malalignment. It was hypothesized that a significant improvement in knee function and reduction in pain would be achieved. Moreover, no conversion to patellofemoral joint arthroplasty could be observed.
View Article and Find Full Text PDFPexidartinib (PLX3397) is a small molecule receptor tyrosine kinase inhibitor of colony stimulating factor 1 receptor (CSF1R) with moderate selectivity over other members of the platelet derived growth factor receptor family. It is approved for treatment of tenosynovial giant cell tumors (TGCT). CSF1R is highly expressed by microglia, which are macrophages of the central nervous system (CNS) that defend the CNS against injury and pathogens and contribute to synapse development and plasticity.
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