Publications by authors named "M W Shafer"

Technological change has affected human health dating back to at least the Neolithic agricultural revolution. Growing evidence indicates widespread environmental pollution began with metallurgical practices and continues today. Environmental exposures to trace elements released from these practices have the potential to alter human body composition, such as bone mineral chemistry, especially for elements that are not homeostatically regulated.

View Article and Find Full Text PDF

Although rare in the general population, pulmonary fungal infections usually occur in immunocompromised patients. The mainstay of pulmonary fungal infection treatment is prolonged intravenous antifungal therapy. However, surgical management may be required in cases of complex disease, resistance to medical therapy or percutaneous procedures, or associated complications such as fungal empyema and massive hemoptysis.

View Article and Find Full Text PDF
Article Synopsis
  • * Identifying high-risk patients is possible through TP53 and RB1 mutations, but there are currently no strategies to prevent this transformation.
  • * Targeting the CDC7 kinase with the inhibitor simurosertib may block NE transformation and improve responses to both targeted and standard chemotherapy in experimental models, indicating a potential new treatment approach for these cancers.
View Article and Find Full Text PDF

The cross-field transport in the scrape-off-layers (SOLs) and divertors in tokamaks is of a similar size to the poloidal component of the parallel flow, thereby significantly impacting the plasma transport there. However, its direct observation has been challenging because the drift velocity (102-103 m/s) is significantly below the detection limit of conventional diagnostics. To realize cross-field ion flow measurement, a variety of systematic uncertainties in the system must be narrowed down.

View Article and Find Full Text PDF

Introduction: This study examined the impact of statutory revisions in 2016 which aimed to enhance procedural justice within the process of civil commitment for persons diagnosed with mental illnesses (PDMI) in South Korea. These changes included requiring that PDMI pose a threat of danger to self or others and the need for treatment simultaneously as criteria for petitioning civil commitment. Additionally, the revision established a public entity to oversee the legitimacy of petitions to involuntarily commit PDMI to inpatient treatment.

View Article and Find Full Text PDF