Publications by authors named "M W Saint-Jean"
Article Synopsis
- Immune checkpoint inhibitors (ICI) have transformed cancer treatment but can lead to rare and serious neurological side effects, such as chronic intestinal pseudo-obstruction (CIPO).
- CIPO may be linked to T cell infiltration and presents with vague symptoms like nausea and constipation, complicating diagnosis and treatment.
- In three cases treated with vedolizumab after corticosteroids failed, there was minimal improvement, suggesting vedolizumab is not an effective option for ICI-induced CIPO at this time.
Article Synopsis
- * A study analyzed 12 patients, highlighting key signs like lack of response to antibiotics, symptom improvement after immunosuppressants, and concurrent immune-related issues, suggesting that this sinusitis is noninfectious.
- * There is a need for more studies to determine how common this condition is and its potential impact on patients' outcomes when treated with ICIs.
Real-world outcomes of combined lenvatinib and anti-PD-1 in advanced melanoma: the Lenvamel study, a multicenter retrospective study of the French Group of Skin Cancers (Groupe de Cancérologie Cutanée).
Oncologist
October 2024
Background: Currently, treatment options for patients with advanced melanoma who experience failed immunotherapy or targeted therapy are lacking. Recent studies suggest the antitumor activity of combined pembrolizumab and lenvatinib in patients with advanced melanoma progressing on immunotherapy. Herein, we report the clinical outcomes of combined lenvatinib and a programmed cell death protein-1 inhibitor (PD-1) in this population.
View Article and Find Full Text PDFThe possibility of an autoparametric resonance in an isolated many-particle system induces a specific behavior of the particles in the presence of thermal noise. In particular, the variance associated with a resonant mode, and consequently that of the associated particles, is strongly increased compared to what it would have in the absence of parametric resonance. In this paper we consider a dimer submitted to a periodic potential for which there are only two modes, the center of mass motion and the internal vibration mode.
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