Publications by authors named "M W Quimby"

Article Synopsis
  • Research aims to identify how tau PET imaging correlates with clinical decline in atypical Alzheimer's disease (AD) to improve patient care.
  • Despite known tau accumulation in atypical AD, its predictive value for clinical decline is still uncertain.
  • Findings show tau levels in the default mode network are strong predictors of decline, outperforming other clinical and imaging factors in patients with atypical AD.
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Background: Informing humanitarian action directly from community members is recognized as critical. However, collecting community insights is also a challenge in practice. This paper reports data collected among community members and Red Crescent volunteers in the occupied Palestinian territory.

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Neurodegenerative dementia syndromes, such as primary progressive aphasias (PPA), have traditionally been diagnosed based, in part, on verbal and non-verbal cognitive profiles. Debate continues about whether PPA is best divided into three variants and regarding the most distinctive linguistic features for classifying PPA variants. In this cross-sectional study, we initially harnessed the capabilities of artificial intelligence and natural language processing to perform unsupervised classification of short, connected speech samples from 78 pateints with PPA.

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Introduction: Recent success has been achieved in Alzheimer's disease (AD) clinical trials targeting amyloid beta (β), demonstrating a reduction in the rate of cognitive decline. However, testing methods for amyloid-β positivity are currently costly or invasive, motivating the development of accessible screening approaches to steer patients toward appropriate diagnostic tests. Here, we employ a pre-trained language model (Distil-RoBERTa) to identify amyloid-β positivity from a short, connected speech sample.

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