Publications by authors named "M W Quasney"
Article Synopsis
- The A allele of rs334 in the β-globin gene significantly predicts pneumonia in African American adults, and this study explores its impact on African American children.
- Genome-wide association analyses were conducted on 482 children with pneumonia and 2,048 controls, revealing rs334 as the most significant variant when using imputed genotypes from a specific reference panel.
- The findings suggest that, like in adults, genetic variations in the β-globin locus that increase the risk for sickle cell disease are also the strongest predictors of pneumonia in African American children.
Article Synopsis
- Sepsis is a serious condition affecting children with limited treatment options due to patient variability; this study aimed to analyze different subclasses of pediatric septic shock.
- Researchers used latent profile analyses on data from 1071 children to identify two phenotypes of septic shock, where Phenotype 1 had worse outcomes compared to Phenotype 2.
- The study found that Phenotype 1 was associated with specific biomarkers indicating high risk, but there was no significant difference in treatment outcomes between the phenotypes; transcriptomic analysis suggested distinct immune responses in Phenotype 1.
Objectives: Post-ICU admission cumulative positive fluid balance (PFB) is associated with increased mortality among critically ill patients. We sought to test whether this risk varied across biomarker-based risk strata upon adjusting for illness severity, presence of severe acute kidney injury (acute kidney injury), and use of continuous renal replacement therapy (CRRT) in pediatric septic shock.
Design: Ongoing multicenter prospective observational cohort.
Background: Sepsis poses a grave threat, especially among children, but treatments are limited due to clinical and biological heterogeneity among patients. Thus, there is an urgent need for precise subclassification of patients to guide therapeutic interventions.
Methods: We used clinical, laboratory, and biomarker data from a prospective multi-center pediatric septic shock cohort to derive phenotypes using latent profile analyses.
Background: Endothelial activation is a key driver of multiple organ dysfunction syndrome (MODS). Soluble endoglin (sENG) is expressed by mature and progenitor endothelial cells and thought to have angiogenic properties. We sought to determine the association between sENG and pediatric sepsis-associated MODS.
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