Identification of a Distinct Monocyte-Driven Signature in Systemic Sclerosis Using Biophysical Phenotyping of Circulating Immune Cells.

Objective: Pathologically activated circulating immune cells, including monocytes, play major roles in systemic sclerosis (SSc). Their functional characterization can provide crucial information with direct clinical relevance. However, tools for the evaluation of pathologic immune cell activation and, in general, of clinical outcomes in SSc are scarce.

[MORPHOLOGICAL ALTERATIONS IN THE INTERNAL ORGANS OF RATS WITH ALLOXAN DIABETES].

The aim of our study was to assess morphological changes in internal organs in a redox-induced model of alloxan diabetes in rats.According to the results of the study, the blood glucose level in rats began to increase 24 hours after the of alloxan administration, reached the maximum level on the 15th day of observation, and decreased on the 25-35 day, to the control level. In parallel with the increase in blood glucose level, an increase in the malondialdehyde (MDA) content in the blood serum was observed.

BIOCHEMICAL ASPECTS OF SYMPTOMATIC TREATMENT IN PATIENTS WITH COVID-19 (REVIEW).

The new Coronavirus has challenged modern medicine. The disease caused by this virus, COVID-19, is characterized by a high rate of lethality, especially in the older age group. There is still no vaccine and no specific treatment, therefore prevention remains the main way to fight the virus.

Role of free nitrogen and oxygen radicals in the pathogenesis of lipopolysaccharide-induced endotoxemia.

We studied molecular mechanisms of changes in oxidative metabolism under conditions of experimental lipopolysaccharide-induced endotoxemia. Generation of reactive nitrogen and oxygen species in mice increased 18 h after treatment with lipopolysaccharide. These changes contributed to inactivation of enzymes and enzyme complexes (ribonucleotide reductase, NADH-ubiquinone oxidoreductase, and cytochrome c oxidase), dysfunction of the mitochondrial electron transport chain, and development of oxidative stress.

[The role of some pituitary hormones in patients with non-insulin-dependent diabetes mellitus and diabetic retinopathy].

The level of somatotropin and thyreotropin hormones was measured in blood plasma of patients with non-insulin-dependent diabetes mellitus with and without diabetic retinopathy (DR). Fifty eight patients (26 males and 32 females) aged from 35 to 75 were examined. The patients were divided into two groups.