Publications by authors named "M W O'Hara"
The increasing threat of antibiotic resistance underscores the urgent need for innovative strategies to combat infectious diseases, including the development of antivirulants. Microbial pathogens rely on their virulence factors to initiate and sustain infections. Antivirulants are small molecules designed to target virulence factors, thereby attenuating the virulence of infectious microbes.
View Article and Find Full Text PDFBackground: Human papillomavirus (HPV)-driven cancers include head and neck squamous cell carcinoma and cervical cancer and represent approximately 5% of all cancer cases worldwide. Standard-of-care chemotherapy, radiotherapy, and immune checkpoint inhibitors (ICIs) are associated with adverse effects and limited responses in patients with HPV-driven cancers. The integration of targeted therapies with ICIs may improve outcomes.
View Article and Find Full Text PDFPurpose: Effective therapy for recurrent head and neck squamous cell carcinoma (HNSCC) that is refractory to chemotherapy and immunotherapy is a considerable need. Aurora kinase A inhibition leads to apoptosis and immunogenic cell death in preclinical models of human papilloma virus (HPV)-driven cancers.
Experimental Design: Alisertib was administered orally twice daily on days 1-7 and pembrolizumab on day 1 of a 21-day cycle to adults with advanced solid tumors (phase 1) or with immunotherapy- and platinum-resistant, HPV-positive HNSCC (phase 2).
Article Synopsis
- Autism prevalence in the U.S. more than increased fourfold from 2000 to 2020, prompting research into factors that contribute to autistic traits in children.
- A study focused on children exposed to prenatal maternal stress (PNMS) during a natural disaster (2008 Iowa floods) found that a mother's subjective distress significantly predicted the severity of autistic-like traits in her children.
- The study revealed that maternal distress during pregnancy had a lasting impact on these traits from ages 4 to 7, while other factors like objective hardship or timing didn't show significant effects.
Article Synopsis
- A diagnosis of behavioral variant frontotemporal dementia (bvFTD) often depends on reports from informants about noticeable behavioral changes in patients.
- The term "bvFTD-by-proxy" refers to cases where changes are reported only by informants, which can lead to questions about the reliability of their observations.
- Three case studies illustrated that symptoms resembling bvFTD were reported by spouses, but medical tests showed only mild issues, highlighting the risks of inaccurate informant reports and the need for careful, coordinated care to protect patient autonomy.