Publications by authors named "M W Mah"
Article Synopsis
- The Linearbandkeramik (LBK) Neolithic communities were pioneers in spreading agriculture across Europe and this study showcases genetic data from 250 individuals to understand their ancestry.
- The findings reveal a notable difference in ancestry, with eastern LBK sites having a higher percentage of western hunter-gatherer genetics compared to western sites, indicating separate genetic paths for these groups.
- Additionally, the research suggests a patrilocal social structure, featuring more genetic connections among males within sites, and points out that the massacre at Asparn-Schletz likely involved individuals from a large population rather than a small community.
Background: Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully understood.
Methods: We used a variety of rodent and human experimental model systems to determine whether exercise training can reduce tumor burden in breast cancer and to identify mechanism associated with any exercise training effects on tumor burden.
Results: We show that voluntary wheel running slows tumor development in the mammary specific polyomavirus middle T antigen overexpression (MMTV-PyMT) mouse model of breast cancer but only when mice are not housed alone.
Article Synopsis
- - The study introduces a method to identify natural selection signals in ancient DNA by analyzing trends in allele frequency changes over 14,000 years across a large population, revealing 347 significant genetic loci with strong selection evidence.
- - Findings indicate that traditional hard sweeps of advantageous mutations have been rare in human evolution, but recently (in the last 10,000 years), many alleles have shown strong directional selection, with notable increases in traits like celiac disease risk and blood type B.
- - The research suggests coordinated selection on traits affecting body fat, skin color, and cognitive performance, pointing to a shift in adaptive strategies as environments changed, although the exact adaptive traits from the past remain unclear.
Consumption of a diet rich in saturated fat increases lipid absorption from the intestine, assembly into chylomicrons, and delivery to metabolic tissues via the lymphatic and circulatory systems. Accumulation of ceramide lipids, composed of sphingosine and a fatty acid, in metabolic tissues contributes to the pathogenesis of cardiovascular diseases, type 2 diabetes mellitus and cancer. Using a mesenteric lymph duct cannulated rat model, we showed that ceramides are generated by the intestine and assembled into chylomicrons, which are transported via the mesenteric lymphatic system.
View Article and Find Full Text PDFThe aim of this study was to evaluate the accuracy of the KardiaMobile (KM) device in adults with a Fontan palliation, and to assess the KM function as a screening tool for atrial arrhythmias. While patient driven electrocardiogram (EKG) devices are becoming a validated way to evaluate cardiac arrhythmias, their role for patients with congenital heart disease is less clear. Patients with single ventricle Fontan palliation have a high prevalence of atrial arrhythmias and represent a unique cohort that could benefit from early detection of atrial arrhythmias.
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