Mai mana: Exploring Pacific peoples' experiences of resilience in Aotearoa.

Objectives: Using a multimethod approach, this study sought to identify the contribution of different facets of resilience to Pacific peoples in Aotearoa New Zealand's mental health and well-being and to explore the construct of resilience in the light of COVID-19 lockdowns.

Method: Study 1 ( = 88) included a Pacific community sample (67% female, 33% male; = 39 years, range = 19-80 years). Participants completed a survey measuring personal, spiritual, family and community resilience, well-being, Pacific identity, and mental distress.

Bias in Prediction Models to Identify Patients With Colorectal Cancer at High Risk for Readmission After Resection.

Purpose: Machine learning algorithms are used for predictive modeling in medicine, but studies often do not evaluate or report on the potential biases of the models. Our purpose was to develop clinical prediction models for readmission after surgery in colorectal cancer (CRC) patients and to examine their potential for racial bias.

Methods: We used the 2012-2020 American College of Surgeons' National Surgical Quality Improvement Program (ACS-NSQIP) Participant Use File and Targeted Colectomy File.

Critical reflection and action in response to an anti-immigration context: What we can learn from migrant young adults from Latin America.

Migrant youth from Latin America who arrive in the United States are faced with a social and political context that dehumanizes migrants of color. These anti-immigrant sentiments become reflected in federal and state policies that deny migrants rights to freedom and safety. The present paper examined how the U.

Impact of parent-reported antibiotic allergies on paediatric Antimicrobial Stewardship Programs.

Background: Antimicrobial stewardship (AMS) is crucial for optimising antimicrobial use and restraining emergence of antimicrobial resistance. The overall increase in reported antibiotic allergies in children can pose a significant barrier to AMS, but its impact on clinical AMS care in children has not been addressed.

Objective: Compare the clinical outcomes for children with a reported antibiotic allergy label (AAL) with those with no AAL reviewed by AMS.

TDP43 autoregulation gives rise to dominant negative isoforms that are tightly controlled by transcriptional and post-translational mechanisms.

The nuclear RNA-binding protein TDP43 is integrally involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Previous studies uncovered N-terminal TDP43 isoforms that are predominantly cytosolic in localization, prone to aggregation, and enriched in susceptible spinal motor neurons. In healthy cells, however, these shortened (s)TDP43 isoforms are difficult to detect in comparison to full-length (fl)TDP43, raising questions regarding their origin and selective regulation.