Publications by authors named "M W Heymans"
Background: Inhibitor eradication to restore factor (F)VIII efficacy is the treatment goal for persons with severe hemophilia A (HA) and inhibitors. Immune tolerance induction (ITI) is demanding and successful in about 70% of people. Until now, it has remained difficult to quantify the probability of ITI success or failure, complicating the decision to initiate or not initiate ITI.
View Article and Find Full Text PDFBackground Context: Lumbar microdiscectomy is an effective treatment for short-term pain relief and improvements in disability in patients with lumbar radiculopathy, however, many patients experience residual pain and long-term disability. The 'people like me' approach seeks to enhance personalized prognosis and treatment effectiveness, utilizing historical data from similar patients to forecast individual outcomes.
Purpose: The primary objective was to develop and test the 'people-like-me' approach for leg pain intensity and disability at 12-month follow-up after lumbar microdiscectomy and postoperative physical therapy.
Background: Low back pain is the leading cause of global disability for which exercise therapy is a widely recommended treatment. Research indicates that contextual factors may also influence treatment outcomes in low back pain. Examples include the patient-therapist relationship and other treatment-related circumstances that affect patient expectations.
View Article and Find Full Text PDFArticle Synopsis
- The World Falls Guidelines (WFG) propose a fall risk classification system (low, intermediate, high) and were evaluated against other fall screening tools, like the AGS/BGS algorithm and fall history.
- A study with 1509 older adults assessed falls over one year, using various methods to measure the algorithm’s predictive performance.
- The WFG algorithm can effectively identify fall risk, especially when using the 3KQ tool, but shows similar performance to other tools, with the 3KQ being more sensitive but less specific.
Aims: Although the neuroanatomical distribution of tau and amyloid-β is well studied in Alzheimer's disease (AD) (non)-amnestic clinical variants, that of neuroinflammation remains unexplored. We investigate the neuroanatomical distribution of activated myeloid cells, astrocytes, and complement alongside amyloid-β and phosphorylated tau in a clinically well-defined prospectively collected AD cohort.
Methods: Clinical variants were diagnosed antemortem, and brain tissue was collected post-mortem.