Pridopidine in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.

Importance: Amyotrophic lateral sclerosis (ALS) is a fatal disease. The sigma-1 (σ1) receptor emerged as a target for intervention.

Objective: To determine the effects of pridopidine, a σ1-receptor agonist, in ALS.

The Safety Profile of Pridopidine, a Novel Sigma-1 Receptor Agonist for the Treatment of Huntington's Disease.

Background: Huntington's disease (HD) is a rare, fatal, chronic progressive neurodegenerative disorder with a significant unmet medical need for effective treatments. Pridopidine is a novel, first-in-class, highly selective and potent sigma-1 receptor (S1R) agonist in development for HD. Pridopidine has been extensively studied in adult HD across the full spectrum of disease severity and age ranges, and its safety profile has been characterized in approximately 1600 participants across multiple studies and a broad range of doses.

Influence of electrical- and gas-stunned broilers on sensory characteristics and consumer acceptance during chilled storage.

Electrical stunning is the most common method of stunning in the poultry industry worldwide, but with a growing demand for prioritizing animal welfare, gas stunning can be an acceptable alternative. This study investigated the effect of electrical and gas stunning on the sensory characteristics and consumer acceptance of chicken breast meat in addition to the impact of packaging type during chilled storage on the flavor of chicken breasts (6 and 18 days for non-vacuum and vacuum packaged, respectively, at 4°C). On Day 0 postmortem, regular chicken consumers (n = 90) were asked to taste oven-baked (165°F, ∼40 min) electrical- and gas-stunned chicken breasts.

Using genotype imputation to integrate Canola populations for genome-wide association and genomic prediction of blackleg resistance.

Background: Integrating germplasm populations genotyped by different genotyping platforms via genotype imputation is a way to utilize accumulated genetic resources. In this study, we used 278 canola samples genotyped via whole-genome sequencing (WGS) at 10× coverage to evaluate the imputation accuracy of three imputation approaches. The optimal imputation methods were used to impute and integrate two Canola genotype datasets: a diverse canola collection genotyped by genotyping-by-sequencing via transcriptome (GBS-t) and a double haploid (DH) line collection genotyped with low-coverage WGS (skim-WGS).

Candida auris Outbreak and Epidemiologic Response in Burn Intensive Care Unit, Illinois, USA, 2021-2023.

Candida auris is an emerging fungal pathogen associated with outbreaks in healthcare settings. We report a multiyear outbreak of C. auris in a burn intensive care unit in Illinois, USA, during 2021-2023.