Publications by authors named "M W Haverkort"
This study compared the dynamics of SARS-CoV-2 viral shedding in saliva between wild-type virus-infected and Omicron-infected household cohorts. Pre-existing immunity in participants likely shortens the viral RNA shedding duration and lowers viral load peaks. Frequent saliva sampling can be a convenient tool to study viral load dynamics.
View Article and Find Full Text PDFCost-effectiveness of a nurse-led sexual rehabilitation intervention for women treated with radiotherapy for gynaecological cancer in a randomized trial.
Radiother Oncol
December 2024
Purpose: To compare the cost-effectiveness of a nurse-led sexual rehabilitation intervention with standard care in women treated with external beam radiotherapy, with or without brachytherapy, for gynaecological cancers.
Methods: Eligible women were randomly assigned to the intervention (n = 112) or standard care (n = 117). Primary endpoint was sexual functioning at 12-months post-radiotherapy, assessed by the Female Sexual Function Index (FSFI).
Of the 4 molecular subtypes of endometrial cancer (EC), p53-abnormal (p53abn) EC is associated with abundant copy number alterations and the worst clinical outcome. Patients with p53abn EC have the highest risk of disease recurrence and death, independent of tumor grade and histologic subtype. Currently, all invasive p53abn ECs are considered high risk, and no prognostic biomarkers have yet been found that can aid in clinical management.
View Article and Find Full Text PDFBackground: Knowledge of SARS-CoV-2 household transmission dynamics guides infection control and vaccination measures. This household cohort study prospectively assessed the impact of both the Omicron BA.2 variant and immunity on household transmission using dense saliva sampling and sequence analysis.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate the prevalence of Pediatric Post-COVID-19 Condition (PPCC), identify associated risk factors, and evaluate the quality of life in children based on the severity of their acute COVID-19 illness.
- A total of 579 children participated, with 260 experiencing mild COVID-19, 60 with severe disease, and 259 as a control group; results indicated that those with severe COVID-19 had a significantly higher prevalence of PPCC compared to mild cases and controls.
- Findings showed that while prevalence of PPCC decreased over time, children exhibiting PPCC had worse physical health-related quality of life and fatigue, with risk factors including prior health issues, hospitalizations, and ongoing fatigue one month post-infection.