Obesity increases DNA damage in the breast epithelium.

Obesity is a modifiable risk factor for breast cancer. Yet, how obesity contributes to cancer initiation is not fully understood. The goal of this study was to determine if the body mass index (BMI) and metabolic hallmarks of obesity are related to DNA damage in normal breast tissue.

Antioxidant and antimicrobial activities of methanolic extract and its phytochemical characterization.

Methanolic extract from was investigated for its phytochemical content, antioxidant, and antimicrobial properties against phytopathogenic fungi and bacteria. Phytochemical analysis revealed the presence of saponin, tannins, and alkaloids with 1.25%, 18.

Insight into the synthesis, structure affirmation and catalytic efficiency of divalent and trivalent metal chelates of mandelic acid hydrazone derivative.

The current work reports the synthesis of Cr(iii), Mn(ii), Co(ii), Ni(ii) and Cu(ii) chelates of the Schiff base ligand named hydroxy-phenyl-acetic acid (2-hydroxy-naphthalen-1-ylmethylene)-hydrazide with multi-chelation centre toward metal ions. The spectral tools, H-NMR, FTIR, mass, UV-vis spectra, and the analytical elemental and thermal analysis, in addition to magnetic moment and conductivity measurements all combined have been applied to conclude the structure and geometry of the synthesized metal complexes. The formed metal chelates have been assured to be formed with the molar compositions of 1 L : 1 M for PANH-Cr, PANH-Mn, PANH-Co, PANH-Ni and 2 L : 1 M for PANH-Cu.

Deoxytrifluoromethylation/aromatization of cyclohexan(en)ones to access highly substituted trifluoromethyl arenes.

Trifluoromethyl arenes (Ar-CF) are amongst the commonly encountered fluorinated substructures in pharmaceutical, agrochemical, and material sciences. However, predominant methods to access Ar-CF possess several limitations, including harsh conditions, lack of availability of substrates, and poor regioselectivity, which combined restrict access to desirable highly functionalized Ar-CF-containing compounds. To expand the scope of accessible Ar-CF-based molecules, we present an orthogonal deoxyfluoroalkylation/aromatization approach that exploits readily accessible and programable cyclohexan(en)one substrates, which undergo a reliable 1,2-addition reaction with the Ruppert-Prakash reagent (TMSCF) followed by aromatization to deliver highly functionalized Ar-CF compounds in a one/two-pot sequence.