Publications by authors named "M W Fear"
Identifying outcomes that matter most is key in driving specialized paediatric burn care. The aim of this study was to discover the most important outcomes for paediatric burns. Parents of children (0-3 year and 4-11 years old) and adolescents (12-17 yearss old) completed surveys to identify outcomes that matter most in the short-term (<6 months postburn) and long-term (6-24 months postburn).
View Article and Find Full Text PDFWhilst wound repair in severe burns has received substantial research attention, non-severe burns (<20 % total body surface area) remain relatively understudied, despite causing considerable physiological impact and constituting most of the hospital admissions for burns. Early prediction of healing outcomes would decrease financial and patient burden, and aid in preventing long-term complications from poor wound healing. Lipids have been implicated in inflammation and tissue repair and may play essential roles in burn wound healing.
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- Dupuytren's disease (DD) is a disorder affecting the connective tissue in the hand, with unclear causes, and studies indicate that WNT4, a part of WNT signaling, may play a role in the disease.
- The research involved isolating fibroblasts from both healthy individuals and those with DD in a family setting, using WNT4 siRNA to analyze gene expression changes through RNA sequencing.
- Findings revealed that normal fibroblasts showed significant changes towards a 'DD-like' state when WNT4 was downregulated, suggesting that loss of WNT4 expression is a critical factor in the onset of Dupuytren's disease.
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- Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe skin reactions to drugs, involving immune system responses from CD8 T cells.
- Researchers analyzed skin and blister fluid from 15 SJS/TEN patients using various sequencing techniques, revealing 15 distinct cell types and noting active immune responses in affected areas.
- Key findings indicate that certain T cell receptors and inflammatory markers in skin tissues could be targeted for new treatments, highlighting the role of keratinocytes and T cells in the disease's progression.
After burn injury there is considerable variation in scar outcome, partially due to genetic factors. Scar vascularity is one characteristic that varies between individuals, and this study aimed to identify genetic variants contributing to different scar vascularity outcomes. An exome-wide array association study and gene pathway analysis was performed on a prospective cohort of 665 patients of European ancestry treated for burn injury, using their scar vascularity (SV) sub-score, part of the modified Vancouver Scar Scale (mVSS), as an outcome measure.
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