Publications by authors named "M W Chia"
Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as a surrogate marker for biological variability. We derived a continuous, measured metric, the retinal pigment score (RPS), that quantifies the degree of pigmentation from a colour fundus photograph of the eye. RPS was validated using two large epidemiological studies with demographic and genetic data (UK Biobank and EPIC-Norfolk Study) and reproduced in a Tanzanian, an Australian, and a Chinese dataset.
View Article and Find Full Text PDFIntroduction: The Movement Assessment Battery for Children, 2nd Edition (MABC-2) test is a valuable tool for identifying motor delays in children globally. However, there has been a lack of data for children in Singapore.
Methods: This study compared 175 children in Singapore (SG) aged 3-6 years to MABC-2 data based on the United Kingdom (UK) population, using statistical tests to analyze age, country, and gender effects on motor competence.
Active pharmaceutical ingredients, such as levonorgestrel (LNG), continue to increase in aquatic ecosystems and are detected in environmental matrices; however, their ability to bioaccumulate and cause reproductive, developmental, and biochemical defects in benthic organisms, such as Macrocyclops albidus, is unknown. This study investigated the effects of LNG on the oxidative stress response, reproduction, and development of M. albidus.
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- High grade serous ovarian cancer has two metabolic subtypes: a high OXPHOS subtype that is more chemosensitive and a low OXPHOS subtype that relies on glycolysis and is more drug resistant.
- The low OXPHOS subtype shows higher levels of lactate dehydrogenase and monocarboxylate transporter 4, indicating different metabolic behaviors compared to the high OXPHOS subtype.
- Two imaging techniques, C magnetic resonance spectroscopy and PET scans, can differentiate between these subtypes and track their treatment responses, offering potential clinical applications for patient management.
Background: The impact of prolonged digital device exposure on physical and mental health in children has been widely investigated by the scientific community. Additionally, the lockdown periods due to the COVID-19 pandemic further exposed children to screen time for e-learning activities. The aim of this systematic review (PROSPERO Registration: CRD42022315596) was to evaluate the effect of digital device exposure on children's health.
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