Publications by authors named "M W Brechbiel"

Article Synopsis
  • Representatives from the U.S. Department of Energy (DOE) and the National Institutes of Health (NIH) held meetings that highlighted the potential for health care innovations through better collaboration between the two organizations.
  • The expertise and technology developed in DOE’s physical science labs, particularly in areas like particle physics, can significantly contribute to advancements in medical healthcare.
  • A joint workshop was convened on July 12-13, 2021, to discuss findings and set goals for future collaborative efforts between NIH and DOE.
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We studied the feasibility of using the α-emitting Bi-anti-CD20 therapy with direct bioluminescent tracking of micrometastatic human B-cell lymphoma in a SCID mouse model. A highly lethal SCID mouse model of minimal-tumor-burden disseminated non-Hodgkin lymphoma (NHL) was established using human Raji lymphoma cells transfected to express the luciferase reporter. In vitro and in vivo radioimmunotherapy experiments were conducted.

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Carboxylic acid is a commonly utilized functional group for covalent surface conjugation of carbon nanoparticles that is typically generated by acid oxidation. However, acid oxidation generates additional oxygen containing groups, including epoxides, ketones, aldehydes, lactones, and alcohols. We present a method to specifically enrich the carboxylic acid content on fluorescent nanodiamond (FND) surfaces.

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