Prognostic value of radiologic and pathological response in colorectal cancer liver metastases upon systemic induction treatment: subgroup analysis of the CAIRO5 trial.

Background: RECIST may not be optimal for assessing treatment response with current systemic regimens. We evaluated RECIST, morphologic, and pathologically documented response (pathological response) in patients with initially unresectable colorectal cancer liver-only metastases (CRLM).

Patients And Methods: Four hundred and eighty-nine patients from the phase III CAIRO5 trial were included who were treated with FOLFOX/FOLFIRI/FOLFOXIRI and bevacizumab or panitumumab.

Strong-ties and weak-ties rationalities: toward a mental model of the consequences of kinship intensity.

There is growing evidence of the connection between variations in kinship intensity and cross-cultural differences in psychological traits. Contributing to this literature on kinship intensity, we put forward a mental model to explain the enduring connection between ancestral niche and psychological traits. Our model posits that two primary orientations or dispositions-strong-ties and weak-ties rationalities-have co-evolved with our ancestral niches to perpetuate-by internalizing and reproducing-the social structure (such as preferences for certain attitudes, values, and beliefs) of the ancestral niche.

Large language models, updates, and evaluation of automation tools for systematic reviews: a summary of significant discussions at the eighth meeting of the International Collaboration for the Automation of Systematic Reviews (ICASR).

The eighth meeting of the International Collaboration for the Automation of Systematic Reviews (ICASR) was held on September 7 and 8, 2023, at the University College London, London, England. ICASR is an interdisciplinary group whose goal is to maximize the use of technology for conducting rapid, accurate, and efficient evidence synthesis, e.g.